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Effects of Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus: Comparison of BMI > 30 and < 30 kg/m(2)

BACKGROUND: Recently, many studies focused on type 2 diabetes mellitus (T2DM) patients with body mass index (BMI) < 30 kg/m(2) and suggested that those patients might benefit from Roux-en-Y gastric bypass (RYGB). However, evidence on its effectiveness to improve T2DM patients with BMI < 30 kg/...

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Autores principales: Ke, Zhigang, Li, Fan, Chen, Jing, Gao, Yu, Zhou, Xunmei, Sun, Fang, Li, Chunxue, Liu, Baohua, Li, Qiang, Zhu, Zhiming, Tong, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651707/
https://www.ncbi.nlm.nih.gov/pubmed/28905292
http://dx.doi.org/10.1007/s11695-017-2926-9
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author Ke, Zhigang
Li, Fan
Chen, Jing
Gao, Yu
Zhou, Xunmei
Sun, Fang
Li, Chunxue
Liu, Baohua
Li, Qiang
Zhu, Zhiming
Tong, Weidong
author_facet Ke, Zhigang
Li, Fan
Chen, Jing
Gao, Yu
Zhou, Xunmei
Sun, Fang
Li, Chunxue
Liu, Baohua
Li, Qiang
Zhu, Zhiming
Tong, Weidong
author_sort Ke, Zhigang
collection PubMed
description BACKGROUND: Recently, many studies focused on type 2 diabetes mellitus (T2DM) patients with body mass index (BMI) < 30 kg/m(2) and suggested that those patients might benefit from Roux-en-Y gastric bypass (RYGB). However, evidence on its effectiveness to improve T2DM patients with BMI < 30 kg/m(2) is still lacking. The aim of this study is to explore whether T2DM patients with BMI < 30 kg/m(2) get similar surgical effect from RYGB compared with those patients with BMI > 30 kg/m(2). METHODOLOGY: Seventy patients with uncontrolled T2DM underwent laparoscopic RYGB from May 2010 to December 2015 in the GI Department of Daping Hospital. Weight, BMI, waist circumference, glucose, and lipid metabolic parameters were collected and evaluated at baseline and 1, 3, 6, 12, and 24 months postsurgery. Patients with BMI < 30 kg/m(2) were compared with those with BMI > 30 kg/m(2). RESULTS: Among the 70 patients, 47 (67.1%) BMI < 30 kg/m(2), and 23 (32.9%) BMI > 30 kg/m(2). Patients with BMI < 30 kg/m(2) are significantly older; they are female predominant and have longer duration of diabetes. The complete remission of T2DM was 28.2% of the BMI < 30 kg/m(2) group and 57.9% of the BMI > 30 kg/m(2) group (p = 0.029). There was no significant difference in the change of glucose and lipid metabolic parameters of both groups. FPG, 2hPG, and HbA1c% levels were significantly improved after 1 month (p < 0.05), and then remained essentially stable from the sixth month in both groups. CONCLUSIONS: The 2-year study has shown that RYGB is a safe and effective procedure in treating T2DM with BMI < 30 kg/m(2), although the complete remission of T2DM in the BMI < 30 kg/m(2) group is lower than the BMI > 30 kg/m(2) group.
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spelling pubmed-56517072017-11-01 Effects of Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus: Comparison of BMI > 30 and < 30 kg/m(2) Ke, Zhigang Li, Fan Chen, Jing Gao, Yu Zhou, Xunmei Sun, Fang Li, Chunxue Liu, Baohua Li, Qiang Zhu, Zhiming Tong, Weidong Obes Surg New Concept BACKGROUND: Recently, many studies focused on type 2 diabetes mellitus (T2DM) patients with body mass index (BMI) < 30 kg/m(2) and suggested that those patients might benefit from Roux-en-Y gastric bypass (RYGB). However, evidence on its effectiveness to improve T2DM patients with BMI < 30 kg/m(2) is still lacking. The aim of this study is to explore whether T2DM patients with BMI < 30 kg/m(2) get similar surgical effect from RYGB compared with those patients with BMI > 30 kg/m(2). METHODOLOGY: Seventy patients with uncontrolled T2DM underwent laparoscopic RYGB from May 2010 to December 2015 in the GI Department of Daping Hospital. Weight, BMI, waist circumference, glucose, and lipid metabolic parameters were collected and evaluated at baseline and 1, 3, 6, 12, and 24 months postsurgery. Patients with BMI < 30 kg/m(2) were compared with those with BMI > 30 kg/m(2). RESULTS: Among the 70 patients, 47 (67.1%) BMI < 30 kg/m(2), and 23 (32.9%) BMI > 30 kg/m(2). Patients with BMI < 30 kg/m(2) are significantly older; they are female predominant and have longer duration of diabetes. The complete remission of T2DM was 28.2% of the BMI < 30 kg/m(2) group and 57.9% of the BMI > 30 kg/m(2) group (p = 0.029). There was no significant difference in the change of glucose and lipid metabolic parameters of both groups. FPG, 2hPG, and HbA1c% levels were significantly improved after 1 month (p < 0.05), and then remained essentially stable from the sixth month in both groups. CONCLUSIONS: The 2-year study has shown that RYGB is a safe and effective procedure in treating T2DM with BMI < 30 kg/m(2), although the complete remission of T2DM in the BMI < 30 kg/m(2) group is lower than the BMI > 30 kg/m(2) group. Springer US 2017-09-13 2017 /pmc/articles/PMC5651707/ /pubmed/28905292 http://dx.doi.org/10.1007/s11695-017-2926-9 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle New Concept
Ke, Zhigang
Li, Fan
Chen, Jing
Gao, Yu
Zhou, Xunmei
Sun, Fang
Li, Chunxue
Liu, Baohua
Li, Qiang
Zhu, Zhiming
Tong, Weidong
Effects of Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus: Comparison of BMI > 30 and < 30 kg/m(2)
title Effects of Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus: Comparison of BMI > 30 and < 30 kg/m(2)
title_full Effects of Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus: Comparison of BMI > 30 and < 30 kg/m(2)
title_fullStr Effects of Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus: Comparison of BMI > 30 and < 30 kg/m(2)
title_full_unstemmed Effects of Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus: Comparison of BMI > 30 and < 30 kg/m(2)
title_short Effects of Laparoscopic Roux-en-Y Gastric Bypass for Type 2 Diabetes Mellitus: Comparison of BMI > 30 and < 30 kg/m(2)
title_sort effects of laparoscopic roux-en-y gastric bypass for type 2 diabetes mellitus: comparison of bmi > 30 and < 30 kg/m(2)
topic New Concept
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651707/
https://www.ncbi.nlm.nih.gov/pubmed/28905292
http://dx.doi.org/10.1007/s11695-017-2926-9
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