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Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers

Fenugreek is a dietary supplement for anti-aging and human health. (2S,3R,4S)-4-hydroxyisoleucine (4-HIL), which is extracted from fenugreek seeds, is expected to be a promising orally active drug for diabetes and diabetic nephropathy because of its insulinotropic effect. Although several chemical s...

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Detalles Bibliográficos
Autores principales:	Shi, Xuan, Miyakawa, Takuya, Nakamura, Akira, Hou, Feng, Hibi, Makoto, Ogawa, Jun, Kwon, Yeondae, Tanokura, Masaru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651801/ https://www.ncbi.nlm.nih.gov/pubmed/29057974 http://dx.doi.org/10.1038/s41598-017-13978-w

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