Cargando…

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes

The suite of biological catalysts found in Nature has the potential to contribute immensely to scientific advancements, ranging from industrial biotechnology to innovations in bioenergy and medical intervention. The endeavour to obtain a catalyst of choice is, however, wrought with challenges. Herei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weise, Nicholas J., Ahmed, Syed T., Parmeggiani, Fabio, Galman, James L., Dunstan, Mark S., Charnock, Simon J., Leys, David, Turner, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651878/ https://www.ncbi.nlm.nih.gov/pubmed/29057979 http://dx.doi.org/10.1038/s41598-017-13990-0

Ejemplares similares

Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis
por: Weise, Nicholas J., et al.
Publicado: (2018)

Synthesis of d- and l-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process**
por: Parmeggiani, Fabio, et al.
Publicado: (2015)

Synthesis of d‐ and l‐Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process
por: Parmeggiani, Fabio, et al.
Publicado: (2015)

Fluorescent enzyme-coupled activity assay for phenylalanine ammonia-lyases
por: Moisă, Mădălina E., et al.
Publicado: (2020)

Fungal and Plant Phenylalanine Ammonia-lyase
por: Hyun, Min Woo, et al.
Publicado: (2011)

Genomic Characterization of Phenylalanine Ammonia Lyase Gene in Buckwheat
por: Thiyagarajan, Karthikeyan, et al.
Publicado: (2016)

Purification and Characterization of Phenylalanine Ammonia Lyase from Trichosporon cutaneum
por: Goldson-Barnaby, Andrea, et al.
Publicado: (2013)

Saturation Mutagenesis for Phenylalanine Ammonia Lyases of Enhanced Catalytic Properties
por: Tomoiagă, Raluca Bianca, et al.
Publicado: (2020)

Hybrid Magnetic Cross-Linked Enzyme Aggregates of Phenylalanine Ammonia Lyase from Rhodotorula glutinis
por: Cui, Jian dong, et al.
Publicado: (2014)

The production of l- and d-phenylalanines using engineered phenylalanine ammonia lyases from Petroselinum crispum
por: Tork, Souad Diana, et al.
Publicado: (2019)

Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria
por: Bell, Sean M., et al.
Publicado: (2017)

Robust, site-specifically immobilized phenylalanine ammonia-lyases for the enantioselective ammonia addition of cinnamic acids
por: Boros, Krisztina, et al.
Publicado: (2021)

A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia‐Lyases
por: Bata, Zsófia, et al.
Publicado: (2017)

Immobilization of Cross-Linked Phenylalanine Ammonia Lyase Aggregates in Microporous Silica Gel
por: Cui, Jian Dong, et al.
Publicado: (2013)

Expression and Properties of the Highly Alkalophilic Phenylalanine Ammonia-Lyase of Thermophilic Rubrobacter xylanophilus
por: Kovács, Klaudia, et al.
Publicado: (2014)

Functional and kinetics of two efficient phenylalanine ammonia lyase from Pyrus bretschneideri
por: Li, Guohui, et al.
Publicado: (2023)

Pharmacodynamics, safety, tolerability and pharmacokinetics of a single oral dose of an engineered phenylalanine ammonia-lyase in patients with phenylketonuria
por: Fazio, Timothy Nicholas, et al.
Publicado: (2023)

Characterization of a Putrescine Transaminase From Pseudomonas putida and its Application to the Synthesis of Benzylamine Derivatives
por: Galman, James L., et al.
Publicado: (2018)

Study of the l-Phenylalanine Ammonia-Lyase Penetration Kinetics and the Efficacy of Phenylalanine Catabolism Correction Using In Vitro Model Systems
por: Dyshlyuk, Lyubov, et al.
Publicado: (2021)

Study of the Potential of the Capsule Shell Based on Natural Polysaccharides in Targeted Delivery of the L-Phenylalanine Ammonia-Lyase Enzyme Preparation
por: Babich, Olga, et al.
Publicado: (2020)

A microparticulate based formulation to protect therapeutic enzymes from proteolytic digestion: phenylalanine ammonia lyase as case study
por: Pereira de Sousa, Irene, et al.
Publicado: (2020)

The phenylalanine ammonia lyase (PAL) gene family shows a gymnosperm-specific lineage
por: Bagal, Ujwal R, et al.
Publicado: (2012)

Molecular Cloning and Sequence Analysis of a Phenylalanine Ammonia-Lyase Gene from Dendrobium
por: Jin, Qing, et al.
Publicado: (2013)

Molecular Cloning, Characterization and Expression of the Phenylalanine Ammonia-Lyase Gene from Juglans regia
por: Xu, Feng, et al.
Publicado: (2012)

Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases
por: Tork, Souad Diana, et al.
Publicado: (2022)

Characterisation of the willow phenylalanine ammonia-lyase (PAL) gene family reveals expression differences compared with poplar
por: de Jong, Femke, et al.
Publicado: (2015)

Phenylalanine ammonia-lyase2.1 contributes to the soybean response towards Phytophthora sojae infection
por: Zhang, Chuanzhong, et al.
Publicado: (2017)

“Fishing and Hunting”—Selective Immobilization of a Recombinant Phenylalanine Ammonia-Lyase from Fermentation Media
por: Sánta-Bell, Evelin, et al.
Publicado: (2019)

The effectiveness of plant hydrocolloids at maintaining the quality characteristics of the encapsulated form of L-phenylalanine-ammonia-lyase
por: Babich, Olga, et al.
Publicado: (2019)

Genome-Wide Analysis and Expression Profiling of the Phenylalanine Ammonia-Lyase Gene Family in Solanum tuberosum
por: Mo, Fangyu, et al.
Publicado: (2022)

Phenylalanine Ammonia-Lyase: A Key Gene for Color Discrimination of Edible Mushroom Flammulina velutipes
por: Im, Ji-Hoon, et al.
Publicado: (2023)

Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model
por: Diaz-Trelles, Ramon, et al.
Publicado: (2022)

Tailored Mutants of Phenylalanine Ammonia‐Lyase from Petroselinum crispum for the Synthesis of Bulky l‐ and d‐Arylalanines
por: Filip, Alina, et al.
Publicado: (2018)

Exploring the therapeutic potential of modern and ancestral phenylalanine/tyrosine ammonia-lyases as supplementary treatment of hereditary tyrosinemia
por: Hendrikse, Natalie M., et al.
Publicado: (2020)

The phenylalanine ammonia-lyase gene family in Isatis indigotica Fort.: molecular cloning, characterization, and expression analysis
por: MA, Rui-Fang, et al.
Publicado: (2016)

Expression of phenylalanine ammonia lyases in Synechocystis sp. PCC 6803 and subsequent improvements of sustainable production of phenylpropanoids
por: Kukil, Kateryna, et al.
Publicado: (2022)

Purification and Characterization of Anabaena flos-aquae Phenylalanine Ammonia-Lyase as a Novel Approach for Myristicin Biotransformation
por: Arafa, Asmaa M., et al.
Publicado: (2020)

A Protective Role of Phenylalanine Ammonia-Lyase from Astragalus membranaceus against Saline-Alkali Stress
por: Fan, Lijuan, et al.
Publicado: (2022)

Rapid Screening of Diverse Biotransformations for Enzyme Evolution
por: Kempa, Emily E., et al.
Publicado: (2021)

Rhodotorula glutinis Phenylalanine/Tyrosine Ammonia Lyase Enzyme Catalyzed Synthesis of the Methyl Ester of para-Hydroxycinnamic Acid and its Potential Antibacterial Activity
por: MacDonald, Marybeth C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kb87vl6igni8u5od0o6rmh9ipn