Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance

We have developed a chronic mild stress (MS) mouse model by simply rearing mice on a wire net for 3 weeks and investigated the effects of MS on glucose homeostasis and sleep. MS mice showed impaired glucose tolerance and disturbed sleep. One-week treatment with a histamine H1 receptor antagonist (H1...

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Autores principales: Chikahisa, Sachiko, Harada, Saki, Shimizu, Noriyuki, Shiuchi, Tetsuya, Otsuka, Airi, Nishino, Seiji, Séi, Hiroyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651881/
https://www.ncbi.nlm.nih.gov/pubmed/29057915
http://dx.doi.org/10.1038/s41598-017-14162-w
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author Chikahisa, Sachiko
Harada, Saki
Shimizu, Noriyuki
Shiuchi, Tetsuya
Otsuka, Airi
Nishino, Seiji
Séi, Hiroyoshi
author_facet Chikahisa, Sachiko
Harada, Saki
Shimizu, Noriyuki
Shiuchi, Tetsuya
Otsuka, Airi
Nishino, Seiji
Séi, Hiroyoshi
author_sort Chikahisa, Sachiko
collection PubMed
description We have developed a chronic mild stress (MS) mouse model by simply rearing mice on a wire net for 3 weeks and investigated the effects of MS on glucose homeostasis and sleep. MS mice showed impaired glucose tolerance and disturbed sleep. One-week treatment with a histamine H1 receptor antagonist (H1RA) ameliorated the glucose intolerance and improved sleep quality in MS mice. MS mice showed an increased number of mast cells in both adipose tissue and the brain. Inhibition of mast cell function ameliorated the impairment in both glucose tolerance and sleep. Together, these findings indicate that mast cells may represent an important pathophysiological mediator in sleep and energy homeostasis.
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spelling pubmed-56518812017-10-26 Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance Chikahisa, Sachiko Harada, Saki Shimizu, Noriyuki Shiuchi, Tetsuya Otsuka, Airi Nishino, Seiji Séi, Hiroyoshi Sci Rep Article We have developed a chronic mild stress (MS) mouse model by simply rearing mice on a wire net for 3 weeks and investigated the effects of MS on glucose homeostasis and sleep. MS mice showed impaired glucose tolerance and disturbed sleep. One-week treatment with a histamine H1 receptor antagonist (H1RA) ameliorated the glucose intolerance and improved sleep quality in MS mice. MS mice showed an increased number of mast cells in both adipose tissue and the brain. Inhibition of mast cell function ameliorated the impairment in both glucose tolerance and sleep. Together, these findings indicate that mast cells may represent an important pathophysiological mediator in sleep and energy homeostasis. Nature Publishing Group UK 2017-10-20 /pmc/articles/PMC5651881/ /pubmed/29057915 http://dx.doi.org/10.1038/s41598-017-14162-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chikahisa, Sachiko
Harada, Saki
Shimizu, Noriyuki
Shiuchi, Tetsuya
Otsuka, Airi
Nishino, Seiji
Séi, Hiroyoshi
Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance
title Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance
title_full Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance
title_fullStr Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance
title_full_unstemmed Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance
title_short Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance
title_sort mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651881/
https://www.ncbi.nlm.nih.gov/pubmed/29057915
http://dx.doi.org/10.1038/s41598-017-14162-w
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