Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

PERK signaling is required for cancer invasion and there is interest in targeting this pathway for therapy. Unfortunately, chemical inhibitors of PERK’s kinase activity cause on-target side effects that have precluded their further development. One strategy for resolving this difficulty would be to...

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Detalles Bibliográficos
Autores principales: Feng, Yu-Xiong, Jin, Dexter X., Sokol, Ethan S., Reinhardt, Ferenc, Miller, Daniel H., Gupta, Piyush B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651903/
https://www.ncbi.nlm.nih.gov/pubmed/29057869
http://dx.doi.org/10.1038/s41467-017-01052-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651903/
https://www.ncbi.nlm.nih.gov/pubmed/29057869
http://dx.doi.org/10.1038/s41467-017-01052-y

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