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Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study

OBJECTIVES: To evaluate the possible role of silodosin (a highly selective α(1A)-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. PATIENTS AND METHODS: In all, 40 paediatr...

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Autores principales: Elgalaly, Hazem, Eliwa, Ahmed, Seleem, Mohamed, Salem, Emad, Omran, Mohammed, Shello, Haitham, Abdelwahab, Khalid, Khalil, Salem, Kamel, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651944/
https://www.ncbi.nlm.nih.gov/pubmed/29071151
http://dx.doi.org/10.1016/j.aju.2017.05.005
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author Elgalaly, Hazem
Eliwa, Ahmed
Seleem, Mohamed
Salem, Emad
Omran, Mohammed
Shello, Haitham
Abdelwahab, Khalid
Khalil, Salem
Kamel, Mostafa
author_facet Elgalaly, Hazem
Eliwa, Ahmed
Seleem, Mohamed
Salem, Emad
Omran, Mohammed
Shello, Haitham
Abdelwahab, Khalid
Khalil, Salem
Kamel, Mostafa
author_sort Elgalaly, Hazem
collection PubMed
description OBJECTIVES: To evaluate the possible role of silodosin (a highly selective α(1A)-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. PATIENTS AND METHODS: In all, 40 paediatric patients (27 boys and 13 girls) diagnosed with unilateral, single, radiopaque DUS of <10 mm were included in the study. Their mean (SD, range) age was 8.1 (2.7, 5–17) years. The patients were randomly divided into two groups: Group A, received silodosin 4 mg as a single bedtime dose; and Group B, received placebo as a single bedtime dose. Ibuprofen was prescribed to both groups on-demand for pain episode relief. Patients were followed up biweekly for 4 weeks. The stone expulsion time and rate, pain episodes, analgesic use, and any adverse effects were recorded. RESULTS: The mean (SD) stone size in Group A was 6.6 (1.7) mm and in Group B was 6.7 (1.4) mm (P = 0.4). Two patients were lost to follow-up (one from each group), and one patient in Group A refused to complete the study. The stone-free rate at end of the 4-week treatment period was 88.8% in Group A vs 73.6% in Group B (P = 0.4). The mean (SD) stone expulsion time was 7.0 (4.3) vs 10.4 (4.7) days in groups A and B, respectively (P = 0.02). The mean (SD) number of pain episodes requiring ibuprofen was 2.3 (1.4) vs 4.7 (2.6) episodes in groups A and B, respectively (P < 0.001). Adverse effects (headache and dizziness) were recorded in three patients (16.7%) in Group A, which were mild and none of them discontinued treatment, whilst no adverse effects were recorded in Group B. CONCLUSIONS: The data in the present study show that silodosin can be safely used in the treatment of DUS in children for decreasing time to stone expulsion, pain episodes, and analgesic requirement.
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spelling pubmed-56519442017-10-25 Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study Elgalaly, Hazem Eliwa, Ahmed Seleem, Mohamed Salem, Emad Omran, Mohammed Shello, Haitham Abdelwahab, Khalid Khalil, Salem Kamel, Mostafa Arab J Urol Original Article OBJECTIVES: To evaluate the possible role of silodosin (a highly selective α(1A)-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. PATIENTS AND METHODS: In all, 40 paediatric patients (27 boys and 13 girls) diagnosed with unilateral, single, radiopaque DUS of <10 mm were included in the study. Their mean (SD, range) age was 8.1 (2.7, 5–17) years. The patients were randomly divided into two groups: Group A, received silodosin 4 mg as a single bedtime dose; and Group B, received placebo as a single bedtime dose. Ibuprofen was prescribed to both groups on-demand for pain episode relief. Patients were followed up biweekly for 4 weeks. The stone expulsion time and rate, pain episodes, analgesic use, and any adverse effects were recorded. RESULTS: The mean (SD) stone size in Group A was 6.6 (1.7) mm and in Group B was 6.7 (1.4) mm (P = 0.4). Two patients were lost to follow-up (one from each group), and one patient in Group A refused to complete the study. The stone-free rate at end of the 4-week treatment period was 88.8% in Group A vs 73.6% in Group B (P = 0.4). The mean (SD) stone expulsion time was 7.0 (4.3) vs 10.4 (4.7) days in groups A and B, respectively (P = 0.02). The mean (SD) number of pain episodes requiring ibuprofen was 2.3 (1.4) vs 4.7 (2.6) episodes in groups A and B, respectively (P < 0.001). Adverse effects (headache and dizziness) were recorded in three patients (16.7%) in Group A, which were mild and none of them discontinued treatment, whilst no adverse effects were recorded in Group B. CONCLUSIONS: The data in the present study show that silodosin can be safely used in the treatment of DUS in children for decreasing time to stone expulsion, pain episodes, and analgesic requirement. Elsevier 2017-07-12 /pmc/articles/PMC5651944/ /pubmed/29071151 http://dx.doi.org/10.1016/j.aju.2017.05.005 Text en © 2017 Arab Association of Urology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Elgalaly, Hazem
Eliwa, Ahmed
Seleem, Mohamed
Salem, Emad
Omran, Mohammed
Shello, Haitham
Abdelwahab, Khalid
Khalil, Salem
Kamel, Mostafa
Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_full Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_fullStr Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_full_unstemmed Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_short Silodosin in the treatment of distal ureteric stones in children: A prospective, randomised, placebo-controlled study
title_sort silodosin in the treatment of distal ureteric stones in children: a prospective, randomised, placebo-controlled study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651944/
https://www.ncbi.nlm.nih.gov/pubmed/29071151
http://dx.doi.org/10.1016/j.aju.2017.05.005
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