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Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1

A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially...

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Detalles Bibliográficos
Autores principales:	Raven, Frank, Ward, Joseph F., Zoltowska, Katarzyna M., Wan, Yu, Bylykbashi, Enjana, Miller, Sean J., Shen, Xunuo, Choi, Se Hoon, Rynearson, Kevin D., Berezovska, Oksana, Wagner, Steven L., Tanzi, Rudolph E., Zhang, Can
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652037/ https://www.ncbi.nlm.nih.gov/pubmed/28919280 http://dx.doi.org/10.1016/j.ebiom.2017.08.028

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