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Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice

Zika virus (ZIKV) has become a global public health emergency due to its rapidly expanding range and its ability to cause severe congenital defects such as microcephaly. However, there are no FDA-approved therapies or vaccines against ZIKV infection. Through our screening of viral entry inhibitors,...

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Detalles Bibliográficos
Autores principales: Li, Chunfeng, Zhu, Xingliang, Ji, Xue, Quanquin, Natalie, Deng, Yong-Qiang, Tian, Min, Aliyari, Roghiyh, Zuo, Xiangyang, Yuan, Ling, Afridi, Shabbir Khan, Li, Xiao-Feng, Jung, Jae U., Nielsen-Saines, Karin, Qin, Frank Xiao-Feng, Qin, Cheng-Feng, Xu, Zhiheng, Cheng, Genhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652284/
https://www.ncbi.nlm.nih.gov/pubmed/29033372
http://dx.doi.org/10.1016/j.ebiom.2017.09.034
Descripción
Sumario:Zika virus (ZIKV) has become a global public health emergency due to its rapidly expanding range and its ability to cause severe congenital defects such as microcephaly. However, there are no FDA-approved therapies or vaccines against ZIKV infection. Through our screening of viral entry inhibitors, we found that chloroquine (CQ), a commonly used antimalarial and a FDA-approved drug that has also been repurposed against other pathogens, could significantly inhibit ZIKV infection in vitro, by blocking virus internalization. We also demonstrated that CQ attenuates ZIKV-associated morbidity and mortality in mice. Finally, we proved that CQ protects fetal mice from microcephaly caused by ZIKV infection. Our methodology of focusing on previously identified antivirals in screens for effectiveness against ZIKV proved to be a rapid and efficient means of discovering new ZIKV therapeutics. Selecting drugs that were previously FDA-approved, such as CQ, also improves the likelihood that they may more quickly reach stages of clinical testing and use by the public.