Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee

Isolated chondral defects have a limited capacity to heal and predispose to the development of osteoarthritis. Current surgical management can be unpredictable in outcome. Improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repai...

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Detalles Bibliográficos
Autores principales: Freitag, Julien, Li, Douglas, Wickham, James, Shah, Kiran, Tenen, Abi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652344/
https://www.ncbi.nlm.nih.gov/pubmed/29038190
http://dx.doi.org/10.1136/bcr-2017-220852
Descripción
Sumario:Isolated chondral defects have a limited capacity to heal and predispose to the development of osteoarthritis. Current surgical management can be unpredictable in outcome. Improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair. A 26-year-old athlete presented with a post-traumatic, isolated patella chondral defect. The patient underwent an arthroscopy with removal of a chondral loose body. After failure to symptomatically improve 12 months following surgery, the patient received intra-articular autologous adipose-derived mesenchymal stem cell (ADMSC) therapy.

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