Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee

Isolated chondral defects have a limited capacity to heal and predispose to the development of osteoarthritis. Current surgical management can be unpredictable in outcome. Improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repai...

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Autores principales: Freitag, Julien, Li, Douglas, Wickham, James, Shah, Kiran, Tenen, Abi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652344/
https://www.ncbi.nlm.nih.gov/pubmed/29038190
http://dx.doi.org/10.1136/bcr-2017-220852
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author Freitag, Julien
Li, Douglas
Wickham, James
Shah, Kiran
Tenen, Abi
author_facet Freitag, Julien
Li, Douglas
Wickham, James
Shah, Kiran
Tenen, Abi
author_sort Freitag, Julien
collection PubMed
description Isolated chondral defects have a limited capacity to heal and predispose to the development of osteoarthritis. Current surgical management can be unpredictable in outcome. Improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair. A 26-year-old athlete presented with a post-traumatic, isolated patella chondral defect. The patient underwent an arthroscopy with removal of a chondral loose body. After failure to symptomatically improve 12 months following surgery, the patient received intra-articular autologous adipose-derived mesenchymal stem cell (ADMSC) therapy.
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spelling pubmed-56523442017-10-25 Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee Freitag, Julien Li, Douglas Wickham, James Shah, Kiran Tenen, Abi BMJ Case Rep Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation) Isolated chondral defects have a limited capacity to heal and predispose to the development of osteoarthritis. Current surgical management can be unpredictable in outcome. Improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair. A 26-year-old athlete presented with a post-traumatic, isolated patella chondral defect. The patient underwent an arthroscopy with removal of a chondral loose body. After failure to symptomatically improve 12 months following surgery, the patient received intra-articular autologous adipose-derived mesenchymal stem cell (ADMSC) therapy. BMJ Publishing Group 2017-10-15 /pmc/articles/PMC5652344/ /pubmed/29038190 http://dx.doi.org/10.1136/bcr-2017-220852 Text en © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
Freitag, Julien
Li, Douglas
Wickham, James
Shah, Kiran
Tenen, Abi
Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee
title Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee
title_full Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee
title_fullStr Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee
title_full_unstemmed Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee
title_short Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee
title_sort effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee
topic Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652344/
https://www.ncbi.nlm.nih.gov/pubmed/29038190
http://dx.doi.org/10.1136/bcr-2017-220852
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