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Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease
We present a case of a 57-year-old man who presented with progressive cerebellar dysarthria and cerebellar ataxia. Additional investigations confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML) in the posterior fossa. This is a demyelinating disease of the central nervous syst...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652366/ https://www.ncbi.nlm.nih.gov/pubmed/29025774 http://dx.doi.org/10.1136/bcr-2017-220990 |
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author | Scholten, Paulette Kralt, Peter Jacobs, Bram |
author_facet | Scholten, Paulette Kralt, Peter Jacobs, Bram |
author_sort | Scholten, Paulette |
collection | PubMed |
description | We present a case of a 57-year-old man who presented with progressive cerebellar dysarthria and cerebellar ataxia. Additional investigations confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML) in the posterior fossa. This is a demyelinating disease of the central nervous system, caused by an opportunistic infection with John Cunningham virus. PML has previously been considered a lethal condition, but because of careful monitoring of patients with HIV and of patients using immunosuppressive drugs it is discovered in earlier stages and prognosis can be improved. Our patient had no known immune-compromising state, but further work-up revealed that the PML was most likely the first presentation of a previous untreated autoimmune disorder: sarcoidosis. |
format | Online Article Text |
id | pubmed-5652366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-56523662017-10-25 Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease Scholten, Paulette Kralt, Peter Jacobs, Bram BMJ Case Rep Unusual Presentation of More Common Disease/Injury We present a case of a 57-year-old man who presented with progressive cerebellar dysarthria and cerebellar ataxia. Additional investigations confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML) in the posterior fossa. This is a demyelinating disease of the central nervous system, caused by an opportunistic infection with John Cunningham virus. PML has previously been considered a lethal condition, but because of careful monitoring of patients with HIV and of patients using immunosuppressive drugs it is discovered in earlier stages and prognosis can be improved. Our patient had no known immune-compromising state, but further work-up revealed that the PML was most likely the first presentation of a previous untreated autoimmune disorder: sarcoidosis. BMJ Publishing Group 2017-10-11 /pmc/articles/PMC5652366/ /pubmed/29025774 http://dx.doi.org/10.1136/bcr-2017-220990 Text en © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Unusual Presentation of More Common Disease/Injury Scholten, Paulette Kralt, Peter Jacobs, Bram Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease |
title | Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease |
title_full | Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease |
title_fullStr | Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease |
title_full_unstemmed | Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease |
title_short | Posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease |
title_sort | posterior fossa progressive multifocal leukoencephalopathy: first presentation of an unknown autoimmune disease |
topic | Unusual Presentation of More Common Disease/Injury |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652366/ https://www.ncbi.nlm.nih.gov/pubmed/29025774 http://dx.doi.org/10.1136/bcr-2017-220990 |
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