Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing

After conventional molecular and serologic testing failed to diagnose the cause of illness, deep sequencing identified spotted fever group Rickettsia DNA in a patient’s blood sample. Sequences belonged to R. honei, the causative agent of Flinders Island spotted fever. Next-generation sequencing is p...

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Detalles Bibliográficos
Autores principales: Graham, Rikki M.A., Donohue, Steven, McMahon, Jamie, Jennison, Amy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652451/
https://www.ncbi.nlm.nih.gov/pubmed/29048295
http://dx.doi.org/10.3201/eid2311.170474
Descripción
Sumario:After conventional molecular and serologic testing failed to diagnose the cause of illness, deep sequencing identified spotted fever group Rickettsia DNA in a patient’s blood sample. Sequences belonged to R. honei, the causative agent of Flinders Island spotted fever. Next-generation sequencing is proving to be a useful tool for clinical diagnostics.

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