Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing

After conventional molecular and serologic testing failed to diagnose the cause of illness, deep sequencing identified spotted fever group Rickettsia DNA in a patient’s blood sample. Sequences belonged to R. honei, the causative agent of Flinders Island spotted fever. Next-generation sequencing is p...

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Autores principales: Graham, Rikki M.A., Donohue, Steven, McMahon, Jamie, Jennison, Amy V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652451/
https://www.ncbi.nlm.nih.gov/pubmed/29048295
http://dx.doi.org/10.3201/eid2311.170474
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author Graham, Rikki M.A.
Donohue, Steven
McMahon, Jamie
Jennison, Amy V.
author_facet Graham, Rikki M.A.
Donohue, Steven
McMahon, Jamie
Jennison, Amy V.
author_sort Graham, Rikki M.A.
collection PubMed
description After conventional molecular and serologic testing failed to diagnose the cause of illness, deep sequencing identified spotted fever group Rickettsia DNA in a patient’s blood sample. Sequences belonged to R. honei, the causative agent of Flinders Island spotted fever. Next-generation sequencing is proving to be a useful tool for clinical diagnostics.
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spelling pubmed-56524512017-11-01 Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing Graham, Rikki M.A. Donohue, Steven McMahon, Jamie Jennison, Amy V. Emerg Infect Dis Research Letter After conventional molecular and serologic testing failed to diagnose the cause of illness, deep sequencing identified spotted fever group Rickettsia DNA in a patient’s blood sample. Sequences belonged to R. honei, the causative agent of Flinders Island spotted fever. Next-generation sequencing is proving to be a useful tool for clinical diagnostics. Centers for Disease Control and Prevention 2017-11 /pmc/articles/PMC5652451/ /pubmed/29048295 http://dx.doi.org/10.3201/eid2311.170474 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Graham, Rikki M.A.
Donohue, Steven
McMahon, Jamie
Jennison, Amy V.
Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing
title Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing
title_full Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing
title_fullStr Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing
title_full_unstemmed Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing
title_short Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing
title_sort detection of spotted fever group rickettsia dna by deep sequencing
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652451/
https://www.ncbi.nlm.nih.gov/pubmed/29048295
http://dx.doi.org/10.3201/eid2311.170474
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