Synovial fibroblasts in 2017

Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review describes the role of synovial fibroblasts as cells of the innate immune system and expands on their invol...

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Detalles Bibliográficos
Autor principal: Ospelt, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Rheumatoid Arthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652455/
https://www.ncbi.nlm.nih.gov/pubmed/29081987
http://dx.doi.org/10.1136/rmdopen-2017-000471
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author Ospelt, Caroline
author_facet Ospelt, Caroline
author_sort Ospelt, Caroline
collection PubMed
description Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review describes the role of synovial fibroblasts as cells of the innate immune system and expands on their involvement in inflammation and cartilage destruction in rheumatoid arthritis (RA). Furthermore, epigenetic changes in RA synovial fibroblasts and studies that focused on the identification of different subsets of synovial fibroblasts are discussed.
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spelling pubmed-56524552017-10-27 Synovial fibroblasts in 2017 Ospelt, Caroline RMD Open Rheumatoid Arthritis Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review describes the role of synovial fibroblasts as cells of the innate immune system and expands on their involvement in inflammation and cartilage destruction in rheumatoid arthritis (RA). Furthermore, epigenetic changes in RA synovial fibroblasts and studies that focused on the identification of different subsets of synovial fibroblasts are discussed. BMJ Publishing Group 2017-10-15 /pmc/articles/PMC5652455/ /pubmed/29081987 http://dx.doi.org/10.1136/rmdopen-2017-000471 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Rheumatoid Arthritis
Ospelt, Caroline
Synovial fibroblasts in 2017
title Synovial fibroblasts in 2017
title_full Synovial fibroblasts in 2017
title_fullStr Synovial fibroblasts in 2017
title_full_unstemmed Synovial fibroblasts in 2017
title_short Synovial fibroblasts in 2017
title_sort synovial fibroblasts in 2017
topic Rheumatoid Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652455/
https://www.ncbi.nlm.nih.gov/pubmed/29081987
http://dx.doi.org/10.1136/rmdopen-2017-000471
work_keys_str_mv AT ospeltcaroline synovialfibroblastsin2017

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