Cargando…

Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)

OBJECTIVE: To examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA(1c) and diabetes duration) with brain volumes and vascular pathology on brain MRI and to assess whether the associations of diabetes with brain volumes are mediated by brain vascular pathology....

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider, Andrea L.C., Selvin, Elizabeth, Sharrett, A. Richey, Griswold, Michael, Coresh, Josef, Jack, Clifford R., Knopman, David, Mosley, Thomas, Gottesman, Rebecca F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652590/
https://www.ncbi.nlm.nih.gov/pubmed/28916531
http://dx.doi.org/10.2337/dc17-1185
_version_ 1783273086763663360
author Schneider, Andrea L.C.
Selvin, Elizabeth
Sharrett, A. Richey
Griswold, Michael
Coresh, Josef
Jack, Clifford R.
Knopman, David
Mosley, Thomas
Gottesman, Rebecca F.
author_facet Schneider, Andrea L.C.
Selvin, Elizabeth
Sharrett, A. Richey
Griswold, Michael
Coresh, Josef
Jack, Clifford R.
Knopman, David
Mosley, Thomas
Gottesman, Rebecca F.
author_sort Schneider, Andrea L.C.
collection PubMed
description OBJECTIVE: To examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA(1c) and diabetes duration) with brain volumes and vascular pathology on brain MRI and to assess whether the associations of diabetes with brain volumes are mediated by brain vascular pathology. RESEARCH DESIGN AND METHODS: Cross-sectional study of 1,713 participants in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) (mean age 75 years, 60% female, 27% black, 30% prediabetes, and 35% diabetes) who underwent 3T brain MRI scans in 2011–2013. Participants were categorized by diabetes-HbA(1c) status as without diabetes (<5.7% [reference]), with prediabetes (5.7 to <6.5%), and with diabetes ([defined as prior diagnosis or HbA(1c) ≥6.5%] <7.0% vs. ≥7.0%), with further stratification by diabetes duration (<10 vs. ≥10 years). RESULTS: In adjusted analyses, compared with participants without diabetes and HbA(1c) <5.7%, participants with prediabetes and those with diabetes and HbA(1c) <7.0% did not have significantly different brain volumes or vascular pathology (all P > 0.05), but those with diabetes and HbA(1c) ≥7.0% had smaller total brain volume (β −0.20 SDs, 95% CI −0.31, −0.09), smaller regional brain volumes (including frontal, temporal, occipital, and parietal lobes; deep gray matter; Alzheimer disease signature region; and hippocampus [all P < 0.05]), and increased burden of white matter hyperintensities (WMH) (P = 0.016). Among participants with diabetes, those with HbA(1c) ≥7.0% had smaller total and regional brain volumes and an increased burden of WMH (all P < 0.05) compared with those with HbA(1c) <7.0%. Similarly, participants with longer duration of diabetes (≥10 years) had smaller brain volumes and higher burden of lacunes (all P < 0.05) than those with a diabetes duration <10 years. We found no evidence for mediation by WMH in associations of diabetes with smaller brain volumes by structural equation models (all P > 0.05). CONCLUSIONS: More-severe diabetes (defined by higher HbA(1c) and longer disease duration) but not prediabetes or less-severe diabetes was associated with smaller brain volumes and an increased burden of brain vascular pathology. No evidence was found that associations of diabetes with smaller brain volumes are mediated by brain vascular pathology, suggesting that other mechanisms may be responsible for these associations.
format Online
Article
Text
id pubmed-5652590
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-56525902018-11-01 Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) Schneider, Andrea L.C. Selvin, Elizabeth Sharrett, A. Richey Griswold, Michael Coresh, Josef Jack, Clifford R. Knopman, David Mosley, Thomas Gottesman, Rebecca F. Diabetes Care Epidemiology/Health Services Research OBJECTIVE: To examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA(1c) and diabetes duration) with brain volumes and vascular pathology on brain MRI and to assess whether the associations of diabetes with brain volumes are mediated by brain vascular pathology. RESEARCH DESIGN AND METHODS: Cross-sectional study of 1,713 participants in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) (mean age 75 years, 60% female, 27% black, 30% prediabetes, and 35% diabetes) who underwent 3T brain MRI scans in 2011–2013. Participants were categorized by diabetes-HbA(1c) status as without diabetes (<5.7% [reference]), with prediabetes (5.7 to <6.5%), and with diabetes ([defined as prior diagnosis or HbA(1c) ≥6.5%] <7.0% vs. ≥7.0%), with further stratification by diabetes duration (<10 vs. ≥10 years). RESULTS: In adjusted analyses, compared with participants without diabetes and HbA(1c) <5.7%, participants with prediabetes and those with diabetes and HbA(1c) <7.0% did not have significantly different brain volumes or vascular pathology (all P > 0.05), but those with diabetes and HbA(1c) ≥7.0% had smaller total brain volume (β −0.20 SDs, 95% CI −0.31, −0.09), smaller regional brain volumes (including frontal, temporal, occipital, and parietal lobes; deep gray matter; Alzheimer disease signature region; and hippocampus [all P < 0.05]), and increased burden of white matter hyperintensities (WMH) (P = 0.016). Among participants with diabetes, those with HbA(1c) ≥7.0% had smaller total and regional brain volumes and an increased burden of WMH (all P < 0.05) compared with those with HbA(1c) <7.0%. Similarly, participants with longer duration of diabetes (≥10 years) had smaller brain volumes and higher burden of lacunes (all P < 0.05) than those with a diabetes duration <10 years. We found no evidence for mediation by WMH in associations of diabetes with smaller brain volumes by structural equation models (all P > 0.05). CONCLUSIONS: More-severe diabetes (defined by higher HbA(1c) and longer disease duration) but not prediabetes or less-severe diabetes was associated with smaller brain volumes and an increased burden of brain vascular pathology. No evidence was found that associations of diabetes with smaller brain volumes are mediated by brain vascular pathology, suggesting that other mechanisms may be responsible for these associations. American Diabetes Association 2017-11 2017-09-15 /pmc/articles/PMC5652590/ /pubmed/28916531 http://dx.doi.org/10.2337/dc17-1185 Text en © 2017 by the American Diabetes Association. http://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.
spellingShingle Epidemiology/Health Services Research
Schneider, Andrea L.C.
Selvin, Elizabeth
Sharrett, A. Richey
Griswold, Michael
Coresh, Josef
Jack, Clifford R.
Knopman, David
Mosley, Thomas
Gottesman, Rebecca F.
Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
title Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
title_full Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
title_fullStr Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
title_full_unstemmed Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
title_short Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
title_sort diabetes, prediabetes, and brain volumes and subclinical cerebrovascular disease on mri: the atherosclerosis risk in communities neurocognitive study (aric-ncs)
topic Epidemiology/Health Services Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652590/
https://www.ncbi.nlm.nih.gov/pubmed/28916531
http://dx.doi.org/10.2337/dc17-1185
work_keys_str_mv AT schneiderandrealc diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs
AT selvinelizabeth diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs
AT sharrettarichey diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs
AT griswoldmichael diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs
AT coreshjosef diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs
AT jackcliffordr diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs
AT knopmandavid diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs
AT mosleythomas diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs
AT gottesmanrebeccaf diabetesprediabetesandbrainvolumesandsubclinicalcerebrovasculardiseaseonmritheatherosclerosisriskincommunitiesneurocognitivestudyaricncs