Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes

Islet β-cell dysfunction and aggressive macrophage activity are early features in the pathogenesis of type 1 diabetes (T1D). 12/15-Lipoxygenase (12/15-LOX) is induced in β-cells and macrophages during T1D and produces proinflammatory lipids and lipid peroxides that exacerbate β-cell dysfunction and...

Descripción completa

Detalles Bibliográficos
Autores principales: Hernandez-Perez, Marimar, Chopra, Gaurav, Fine, Jonathan, Conteh, Abass M., Anderson, Ryan M., Linnemann, Amelia K., Benjamin, Chanelle, Nelson, Jennifer B., Benninger, Kara S., Nadler, Jerry L., Maloney, David J., Tersey, Sarah A., Mirmira, Raghavendra G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652601/
https://www.ncbi.nlm.nih.gov/pubmed/28842399
http://dx.doi.org/10.2337/db17-0215

Ejemplares similares

Ejemplares similares