Cargando…

The tumour suppressor CDKN2A/p16(INK4a) regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue

The genomic CDKN2A/B locus, encoding p16(INK4a) among others, is linked to an increased risk for cardiovascular disease and type 2 diabetes. Obesity is a risk factor for both cardiovascular disease and type 2 diabetes. p16(INK4a) is a cell cycle regulator and tumour suppressor. Whether it plays a ro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wouters, Kristiaan, Deleye, Yann, Hannou, Sarah A, Vanhoutte, Jonathan, Maréchal, Xavier, Coisne, Augustin, Tagzirt, Madjid, Derudas, Bruno, Bouchaert, Emmanuel, Duhem, Christian, Vallez, Emmanuelle, Schalkwijk, Casper G, Pattou, François, Montaigne, David, Staels, Bart, Paumelle, Réjane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652646/ https://www.ncbi.nlm.nih.gov/pubmed/28868898 http://dx.doi.org/10.1177/1479164117728012

Ejemplares similares

Bone Marrow p16(INK4a)-Deficiency Does Not Modulate Obesity, Glucose Homeostasis or Atherosclerosis Development
por: Wouters, Kristiaan, et al.
Publicado: (2012)

Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes
por: Kahoul, Yasmina, et al.
Publicado: (2020)

PIEZO1 mechanoreceptor activation reduces adipogenesis in perivascular adipose tissue preadipocytes
por: Rendon, C. Javier, et al.
Publicado: (2022)

The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ
por: Firmin, François F., et al.
Publicado: (2017)

The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions
por: Dubois-Chevalier, Julie, et al.
Publicado: (2017)

A Misleading Left Atrial Appendage
por: Kourtinos, Alexandros, et al.
Publicado: (2023)

Cdkn2a deficiency promotes adipose tissue browning
por: Rabhi, Nabil, et al.
Publicado: (2017)

NASH-related increases in plasma bile acid levels depend on insulin resistance
por: Grzych, Guillaume, et al.
Publicado: (2020)

Hepatic Molecular Signatures Highlight the Sexual Dimorphism of Nonalcoholic Steatohepatitis (NASH)
por: Vandel, Jimmy, et al.
Publicado: (2020)

Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity
por: Eeckhoute, Jérôme, et al.
Publicado: (2012)

Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke
por: Gautier, Sophie, et al.
Publicado: (2014)

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver
por: Dubois, Vanessa, et al.
Publicado: (2020)

Peroxisome Proliferator-Activated Receptor γ Induces the Expression of Tissue Factor Pathway Inhibitor-1 (TFPI-1) in Human Macrophages
por: Chinetti-Gbaguidi, G., et al.
Publicado: (2016)

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
por: Zhao, Ran, et al.
Publicado: (2016)

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα
por: Ratman, Dariusz, et al.
Publicado: (2016)

Deletion of the nuclear receptor RORα in macrophages does not modify the development of obesity, insulin resistance and NASH
por: L’homme, Laurent, et al.
Publicado: (2020)

Sporadic CDKN2 (MTS1/p16ink4) gene alterations in human ovarian tumours.
por: Schuyer, M., et al.
Publicado: (1996)

Weighing in on Adipogenesis
por: Nunn, Elizabeth R., et al.
Publicado: (2022)

Fingolimod treatment modulates PPARγ and CD36 gene expression in women with multiple sclerosis
por: Ferret-Sena, Véronique, et al.
Publicado: (2022)

Loss of Both CDKN2A and CDKN2B Allows for Centrosome Overduplication in Melanoma
por: Patel, Shyamal, et al.
Publicado: (2020)

Mutation analysis of genes that control the G1/S cell cycle in melanoma: TP53, CDKN1A, CDKN2A, and CDKN2B
por: Soto, José Luis, et al.
Publicado: (2005)

CDKN2A/p16INK4(a) expression is associated with vascular progeria in chronic kidney disease
por: Stenvinkel, Peter, et al.
Publicado: (2017)

High liver fibrosis scores in metabolic dysfunction-associated fatty liver disease patients are associated with adverse atrial remodeling and atrial fibrillation recurrence following catheter ablation
por: Decoin, Raphaël, et al.
Publicado: (2022)

Loss of CDKN2A and CDKN2B expression is associated with disease recurrence in oral cancer
por: Deepak Roshan, V G, et al.
Publicado: (2019)

Cardiac contractile function and mitochondrial respiration in diabetes-related mouse models
por: Marciniak, Camille, et al.
Publicado: (2014)

Roles of CDKN1B in cancer?
por: Belletti, Barbara, et al.
Publicado: (2015)

Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients
por: Margerie, Daniel, et al.
Publicado: (2019)

Not the average view of adipogenesis
por: Short, Ben
Publicado: (2009)

CDKN2A (p16(INK4A)) affects the anti-tumor effect of CDK inhibitor in somatotroph adenomas
por: Chen, Yiyuan, et al.
Publicado: (2021)

Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma
por: Jalili, Ahmad, et al.
Publicado: (2012)

Stromal Vascular Cells and Adipogenesis: Cells within Adipose Depots Regulate Adipogenesis
por: Hausman, Gary J., et al.
Publicado: (2013)

Myocardial, Perivascular, and Epicardial Fat
por: Iozzo, Patricia
Publicado: (2011)

Perivascular cells for regenerative medicine
por: Crisan, Mihaela, et al.
Publicado: (2012)

Giant tumefactive perivascular spaces
por: Hao, Xiaodi, et al.
Publicado: (2023)

Why Are Perivascular Spaces Important?
por: Shulyatnikova, Tatyana, et al.
Publicado: (2023)

Molecular Genetics and Functional Analysis Implicate CDKN2BAS1-CDKN2B Involvement in POAG Pathogenesis
por: Rathi, Sonika, et al.
Publicado: (2020)

Novel germline variants of CDKN1B and CDKN2C identified during screening for familial primary hyperparathyroidism
por: Mazarico-Altisent, I., et al.
Publicado: (2022)

DNA methylation in the promoter region of the p16 (CDKN2/MTS-1/INK4A) gene in human breast tumours
por: Woodcock, D M, et al.
Publicado: (1999)

Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis
por: Dehondt, Hélène, et al.
Publicado: (2023)

Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours.
por: Schmidt, E. E., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_u04scjr1lndvrn1grdhtc0e9qh