Activation-induced cytidine deaminase prevents pro-B cell acute lymphoblastic leukemia by functioning as a negative regulator in Rag1 deficient pro-B cells

Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation and class switch recombination in mature B-cells, while AID was also shown to play a role in developing pre-BCR/BCR-positive B-cells of the bone marrow. To further elucidate a potential function of Aid in the bone mar...

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Detalles Bibliográficos
Autores principales: Auer, Franziska, Ingenhag, Deborah, Pinkert, Stefan, Kracker, Sven, Hacein-Bey-Abina, Salima, Cavazzana, Marina, Gombert, Michael, Martin-Lorenzo, Alberto, Lin, Min-Hui, Vicente-Dueñas, Carolina, Sánchez-García, Isidro, Borkhardt, Arndt, Hauer, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652663/
https://www.ncbi.nlm.nih.gov/pubmed/29100269
http://dx.doi.org/10.18632/oncotarget.20563

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