Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb

Renal resistance to loop diuretics is a frequent complication in a number of kidney disease patients with elusive mechanism. Employing human renal biopsy specimens, albumin overload mouse model, and primary cultures of mouse renal tubular cells, albuminuria effect on NKCC2 expression and function an...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhuang, Yibo, Jia, Zhanjun, Hu, Caiyu, Ding, Guixia, Zhang, Xintong, Zhang, Yue, Yang, Guangrui, Rohatgi, Rajeev, Huang, Songming, He, John Ci-Jiang, Zhang, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652664/
https://www.ncbi.nlm.nih.gov/pubmed/29100270
http://dx.doi.org/10.18632/oncotarget.10257

Ejemplares similares

Ejemplares similares