Analytic validation and real-time clinical application of an amplicon-based targeted gene panel for advanced cancer

Multiplex somatic testing has emerged as a strategy to test patients with advanced cancer. We demonstrate our analytic validation approach for a gene hotspot panel and real-time prospective clinical application for any cancer type. The TruSight Tumor 26 assay amplifies 85 somatic hotspot regions acr...

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Detalles Bibliográficos
Autores principales: Wing, Michele R., Reeser, Julie W., Smith, Amy M., Reeder, Matthew, Martin, Dorrelyn, Jewell, Benjamin M., Datta, Jharna, Miya, Jharna, Monk, J. Paul, Mortazavi, Amir, Otterson, Gregory A., Goldberg, Richard M., VanDeusen, Jeffrey B., Cole, Sharon, Dittmar, Kristin, Jaiswal, Sunny, Kinzie, Matthew, Waikhom, Suraj, Freud, Aharon G., Zhou, Xiao-Ping, Chen, Wei, Bhatt, Darshna, Roychowdhury, Sameek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652665/
https://www.ncbi.nlm.nih.gov/pubmed/29100271
http://dx.doi.org/10.18632/oncotarget.20616

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