Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate

Cancer-selective tetra-branched peptides, named NT4, can be coupled to different functional units for cancer cell imaging or therapy. NT4 peptides specifically bind to lipoprotein receptor-related proteins (LRP) receptors and to heparan sulfate chains on membrane proteoglycans and can be efficiently...

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Detalles Bibliográficos
Autores principales: Depau, Lorenzo, Brunetti, Jlenia, Falciani, Chiara, Scali, Silvia, Riolo, Giulia, Mandarini, Elisabetta, Pini, Alessandro, Bracci, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652693/
https://www.ncbi.nlm.nih.gov/pubmed/29100299
http://dx.doi.org/10.18632/oncotarget.19056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652693/
https://www.ncbi.nlm.nih.gov/pubmed/29100299
http://dx.doi.org/10.18632/oncotarget.19056

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