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Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway
Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic pyrophosphate levels, and its expression is correlated with growth of several solid tumors. To investigate this relationship, we first examined PPA1 expression in human epithelial ovarian cancer (EOC) samples, and f...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652704/ https://www.ncbi.nlm.nih.gov/pubmed/29100310 http://dx.doi.org/10.18632/oncotarget.19346 |
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author | Niu, Haiying Zhou, Wei Xu, Yingxi Yin, Zhiqi Shen, Wenzhi Ye, Zhen Liu, Yanhua Chen, Yanan Yang, Shuang Xiang, Rong Wang, Lina Qu, Pengpeng |
author_facet | Niu, Haiying Zhou, Wei Xu, Yingxi Yin, Zhiqi Shen, Wenzhi Ye, Zhen Liu, Yanhua Chen, Yanan Yang, Shuang Xiang, Rong Wang, Lina Qu, Pengpeng |
author_sort | Niu, Haiying |
collection | PubMed |
description | Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic pyrophosphate levels, and its expression is correlated with growth of several solid tumors. To investigate this relationship, we first examined PPA1 expression in human epithelial ovarian cancer (EOC) samples, and found that PPA1 was overexpressed in tumors from EOC patients. Higher PPA1 levels correlated with advanced grades, stages, and poor survival in EOC patients. Examination of PPA1 function in EOC revealed that silencing PPA1 inhibited EOC migration, epithelial-mesenchymal transition (EMT), and metastasis in vitro and in vivo. In addition, PPA1 may promote the dephosphorylation and translocation of β-catenin. These results demonstrate that silencing PPA1 inhibits EOC metastasis by suppressing the Wnt/β-catenin signaling pathway. Strategies for downregulating PPA1 may have therapeutic potential for the prevention and treatment of EOC. |
format | Online Article Text |
id | pubmed-5652704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56527042017-11-02 Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway Niu, Haiying Zhou, Wei Xu, Yingxi Yin, Zhiqi Shen, Wenzhi Ye, Zhen Liu, Yanhua Chen, Yanan Yang, Shuang Xiang, Rong Wang, Lina Qu, Pengpeng Oncotarget Research Paper Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic pyrophosphate levels, and its expression is correlated with growth of several solid tumors. To investigate this relationship, we first examined PPA1 expression in human epithelial ovarian cancer (EOC) samples, and found that PPA1 was overexpressed in tumors from EOC patients. Higher PPA1 levels correlated with advanced grades, stages, and poor survival in EOC patients. Examination of PPA1 function in EOC revealed that silencing PPA1 inhibited EOC migration, epithelial-mesenchymal transition (EMT), and metastasis in vitro and in vivo. In addition, PPA1 may promote the dephosphorylation and translocation of β-catenin. These results demonstrate that silencing PPA1 inhibits EOC metastasis by suppressing the Wnt/β-catenin signaling pathway. Strategies for downregulating PPA1 may have therapeutic potential for the prevention and treatment of EOC. Impact Journals LLC 2017-07-18 /pmc/articles/PMC5652704/ /pubmed/29100310 http://dx.doi.org/10.18632/oncotarget.19346 Text en Copyright: © 2017 Niu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Niu, Haiying Zhou, Wei Xu, Yingxi Yin, Zhiqi Shen, Wenzhi Ye, Zhen Liu, Yanhua Chen, Yanan Yang, Shuang Xiang, Rong Wang, Lina Qu, Pengpeng Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway |
title | Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway |
title_full | Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway |
title_fullStr | Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway |
title_full_unstemmed | Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway |
title_short | Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway |
title_sort | silencing ppa1 inhibits human epithelial ovarian cancer metastasis by suppressing the wnt/β-catenin signaling pathway |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652704/ https://www.ncbi.nlm.nih.gov/pubmed/29100310 http://dx.doi.org/10.18632/oncotarget.19346 |
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