Establishment and characterization of patient-derived xenograft models of gastrointestinal stromal tumor resistant to standard tyrosine kinase inhibitors

Gastrointestinal stromal tumors (GISTs) with KIT or platelet-derived growth factor receptor alpha (PDGFRa) oncogenic driver gene mutations, respond to tyrosine kinase inhibitors (TKIs) including imatinib, sunitinib, and regorafenib. However, most patients develop TKI resistance; therefore, novel age...

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Detalles Bibliográficos
Autores principales: Na, Young-Soon, Ryu, Min-Hee, Yoo, Changhoon, Lee, Ju-Kyung, Park, Jung Min, Lee, Chae-Won, Lee, Sun Young, Shin, Young-Kyoung, Ku, Ja-Lok, Ahn, Sung-Min, Kang, Yoon-Koo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652737/
https://www.ncbi.nlm.nih.gov/pubmed/29100343
http://dx.doi.org/10.18632/oncotarget.20816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652737/
https://www.ncbi.nlm.nih.gov/pubmed/29100343
http://dx.doi.org/10.18632/oncotarget.20816

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