Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α

Trefoil factor 3 (TFF3) plays significant roles in several solid tumors. However, the expression pattern and function of TFF3 in glioblastoma (GBM) have not been reported. Here, we report that expression level of TFF3 significantly elevated in glioma and correlated with the prognosis of glioma patie...

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Detalles Bibliográficos
Autores principales: Diao, Shuo, Zheng, Qianqian, Gao, Jian, Yao, Yiqun, Ren, Siyang, Liu, Yongjian, Xu, Yinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652741/
https://www.ncbi.nlm.nih.gov/pubmed/29100347
http://dx.doi.org/10.18632/oncotarget.20010
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author Diao, Shuo
Zheng, Qianqian
Gao, Jian
Yao, Yiqun
Ren, Siyang
Liu, Yongjian
Xu, Yinghui
author_facet Diao, Shuo
Zheng, Qianqian
Gao, Jian
Yao, Yiqun
Ren, Siyang
Liu, Yongjian
Xu, Yinghui
author_sort Diao, Shuo
collection PubMed
description Trefoil factor 3 (TFF3) plays significant roles in several solid tumors. However, the expression pattern and function of TFF3 in glioblastoma (GBM) have not been reported. Here, we report that expression level of TFF3 significantly elevated in glioma and correlated with the prognosis of glioma patients. Then we found TFF3 promotes proliferation, invasion, and migration and inhibits apoptosis of glioma cells in vitro, and delayed tumor progression in subcutaneous xenograft nude mice, and prolonged the median survival time in orthotopic xenograft mice. Moreover, knockdown of TFF3 reduced the expression of HIF-1α through a hypoxia-independent manner. These findings suggest that targeting TFF3 may offer a novel strategy for therapeutic intervention of malignant gliomas.
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spelling pubmed-56527412017-11-02 Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α Diao, Shuo Zheng, Qianqian Gao, Jian Yao, Yiqun Ren, Siyang Liu, Yongjian Xu, Yinghui Oncotarget Research Paper Trefoil factor 3 (TFF3) plays significant roles in several solid tumors. However, the expression pattern and function of TFF3 in glioblastoma (GBM) have not been reported. Here, we report that expression level of TFF3 significantly elevated in glioma and correlated with the prognosis of glioma patients. Then we found TFF3 promotes proliferation, invasion, and migration and inhibits apoptosis of glioma cells in vitro, and delayed tumor progression in subcutaneous xenograft nude mice, and prolonged the median survival time in orthotopic xenograft mice. Moreover, knockdown of TFF3 reduced the expression of HIF-1α through a hypoxia-independent manner. These findings suggest that targeting TFF3 may offer a novel strategy for therapeutic intervention of malignant gliomas. Impact Journals LLC 2017-08-07 /pmc/articles/PMC5652741/ /pubmed/29100347 http://dx.doi.org/10.18632/oncotarget.20010 Text en Copyright: © 2017 Diao et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Diao, Shuo
Zheng, Qianqian
Gao, Jian
Yao, Yiqun
Ren, Siyang
Liu, Yongjian
Xu, Yinghui
Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α
title Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α
title_full Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α
title_fullStr Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α
title_full_unstemmed Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α
title_short Trefoil factor 3 contributes to the malignancy of glioma via regulating HIF-1α
title_sort trefoil factor 3 contributes to the malignancy of glioma via regulating hif-1α
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652741/
https://www.ncbi.nlm.nih.gov/pubmed/29100347
http://dx.doi.org/10.18632/oncotarget.20010
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