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The conjugated antimetabolite 5-FdU-ECyd and its cellular and molecular effects on platinum-sensitive vs. -resistant ovarian cancer cells in vitro

BACKGROUND: Resistance to platinum-based chemotherapy is a clinical challenge in the treatment of ovarian cancer (OC) and limits survival. Therefore, innovative drugs against platinum-resistance are urgently needed. Our therapeutic concept is based on the conjugation of two chemotherapeutic compound...

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Detalles Bibliográficos
Autores principales:	Schott, Sarah, Wimberger, Pauline, Klink, Barbara, Grützmann, Konrad, Puppe, Julian, Wauer, Ulrike Sophie, Klotz, Daniel Martin, Schröck, Evelin, Kuhlmann, Jan Dominik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652753/ https://www.ncbi.nlm.nih.gov/pubmed/29100359 http://dx.doi.org/10.18632/oncotarget.20260

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