Cargando…

The conjugated antimetabolite 5-FdU-ECyd and its cellular and molecular effects on platinum-sensitive vs. -resistant ovarian cancer cells in vitro

BACKGROUND: Resistance to platinum-based chemotherapy is a clinical challenge in the treatment of ovarian cancer (OC) and limits survival. Therefore, innovative drugs against platinum-resistance are urgently needed. Our therapeutic concept is based on the conjugation of two chemotherapeutic compound...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schott, Sarah, Wimberger, Pauline, Klink, Barbara, Grützmann, Konrad, Puppe, Julian, Wauer, Ulrike Sophie, Klotz, Daniel Martin, Schröck, Evelin, Kuhlmann, Jan Dominik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652753/ https://www.ncbi.nlm.nih.gov/pubmed/29100359 http://dx.doi.org/10.18632/oncotarget.20260

Ejemplares similares

Zn(2+) selectively stabilizes FdU-substituted DNA through a unique major groove binding motif
por: Ghosh, Supratim, et al.
Publicado: (2011)

Malignant Pleural Mesothelioma Outcomes in the Era of Combined Platinum and Folate Antimetabolite Chemotherapy
por: Saint-Pierre, Mathieu D., et al.
Publicado: (2015)

Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells
por: Melnikova, Margarita, et al.
Publicado: (2020)

Platinum-Nucleos(t)ide Compounds as Possible Antimetabolites for Antitumor/Antiviral Therapy: Properties and Perspectives
por: De Castro, Federica, et al.
Publicado: (2023)

A Study of Antimetabolites
Publicado: (1952)

Problems in the Designing of Antimetabolites
por: Mautner, Henry G.
Publicado: (1960)

Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples
por: Zakrzewski, Falk, et al.
Publicado: (2019)

Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells
por: Schleser, Sebastian W., et al.
Publicado: (2023)

Transcriptional response of Bacillus megaterium FDU301 to PEG200-mediated arid stress
por: Zhao, Lei, et al.
Publicado: (2020)

Synthesis of zirconium modified FDU-12 by different methods and its application in dibenzothiophene hydrodesulfurization
por: Meng, Qian, et al.
Publicado: (2018)

Antimetabolite Treatment for Pancreatic Cancer
por: Valenzuela, Malyn May Asuncion, et al.
Publicado: (2014)

Prognostic relevance of longitudinal HGF levels in serum of patients with ovarian cancer
por: Klotz, Daniel Martin, et al.
Publicado: (2021)

Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model
por: Clausing, Maximilian, et al.
Publicado: (2022)

EMT-like circulating tumor cells in ovarian cancer patients are enriched by platinum-based chemotherapy
por: Chebouti, Issam, et al.
Publicado: (2017)

Aluminum Melt Degassing Process Evaluation Depending on the Design and the Degree of the FDU Unit Graphite Rotor Wear
por: Podaril, Martin, et al.
Publicado: (2022)

The levels of soluble cMET ectodomain in the blood of patients with ovarian cancer are an independent prognostic biomarker
por: Klotz, Daniel Martin, et al.
Publicado: (2021)

Enhancement of human chorionic gonadotrophin production by antimetabolites.
por: Browne, P., et al.
Publicado: (1982)

Nucleoside salvage and resistance to antimetabolite anticancer agents.
por: Fox, M., et al.
Publicado: (1991)

New antimetabolites in cancer chemotherapy and their clinical impact.
por: Kaye, S. B.
Publicado: (1998)

Molecular features that predict the response to antimetabolite chemotherapies
por: Mehrmohamadi, Mahya, et al.
Publicado: (2017)

Study on novel modified large mesoporous silica FDU-12/polymer matrix nanocomposites for adsorption of Pb(II)
por: Ghaforinejad, Hamed, et al.
Publicado: (2021)

Role of antimetabolites in recalcitrant idiopathic orbital inflammatory syndrome
por: Priya, Yamini, et al.
Publicado: (2011)

The use of antimetabolites as adjunctive therapy in the surgical treatment of pterygium
por: Kareem, Alyaà Abood, et al.
Publicado: (2012)

Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications
por: Zhou, Wenxu, et al.
Publicado: (2019)

Steroidal Antimetabolites Protect Mice against Trypanosoma brucei
por: Chaudhuri, Minu, et al.
Publicado: (2022)

FD&C Yellow No. 6
Publicado: (1982)

An Introduction of FD-Complete Constraints
por: Löffler, Sven, et al.
Publicado: (2020)

Ectopic expression of Arabidopsis FD and FD PARALOGUE in rice results in dwarfism with size reduction of spikelets
por: Jang, Seonghoe, et al.
Publicado: (2017)

Role of the Forkhead Transcription Factors Fd4 and Fd5 During Drosophila Leg Development
por: Ruiz-Losada, Mireya, et al.
Publicado: (2021)

Overcoming PARP inhibitor resistance in ovarian cancer: what are the most promising strategies?
por: Klotz, Daniel Martin, et al.
Publicado: (2020)

Genes Involved in the Production of Antimetabolite Toxins by Pseudomonas syringae Pathovars
por: Arrebola, Eva, et al.
Publicado: (2011)

SAMHD1 is a barrier to antimetabolite-based cancer therapies
por: Rudd, Sean G., et al.
Publicado: (2017)

Weak Interaction of the Antimetabolite Drug Methotrexate with a Cavitand Derivative
por: Preisz, Zsolt, et al.
Publicado: (2020)

Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan
por: Marlina, Anita, et al.
Publicado: (2023)

Excellent supercapacitance performance of 3-D mesoporous carbon with large pores from FDU-12 prepared using a microwave method
por: Cha, Wang Soo, et al.
Publicado: (2018)

ERCC1-expressing circulating tumor cells as a potential diagnostic tool for monitoring response to platinum-based chemotherapy and for predicting post-therapeutic outcome of ovarian cancer
por: Chebouti, Issam, et al.
Publicado: (2016)

In vio replication and antimetabolite incorporation by coexistent normal and autogenous tumor cells.
por: Post, J., et al.
Publicado: (1968)

Modulation of the Ribonucleotide Reductase-Antimetabolite Drug Interaction in Cancer Cell Lines
por: Zhou, Jun, et al.
Publicado: (2010)

Chemical and Metabolic Aspects of Antimetabolite Toxins Produced by Pseudomonas syringae Pathovars
por: Arrebola, Eva, et al.
Publicado: (2011)

Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase
por: Asuncion Valenzuela, Malyn M, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_aonlu662qt7q55janfem1m3h28