Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides

Many tyrosine kinase-driven cancers, including chronic myeloid leukemia (CML), are characterized by high response rates to specific tyrosine kinase inhibitors (TKIs) like imatinib. In East Asians, primary imatinib resistance is caused by a deletion polymorphism in Intron 2 of the BIM gene, whose pro...

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Detalles Bibliográficos
Autores principales: Liu, Jun, Bhadra, Malini, Sinnakannu, Joanna Rajeswary, Yue, Wan Lin, Tan, Cheryl Weiqi, Rigo, Frank, Ong, S.Tiong, Roca, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652800/
https://www.ncbi.nlm.nih.gov/pubmed/29100409
http://dx.doi.org/10.18632/oncotarget.20658

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