Cargando…

Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis

The goals of this meta-analysis were to assess the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with prostate carcinoma (PCa) and to explore the risk profiles with the highest benefit. Systematic electronic searched were conducted in database. We used p...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Zhiqiang, Zheng, Yi, Ji, Guanghai, Liu, Xinxin, Li, Peng, Cai, Lei, Guo, Yulin, Yang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652829/
https://www.ncbi.nlm.nih.gov/pubmed/29100440
http://dx.doi.org/10.18632/oncotarget.20316
_version_ 1783273138505646080
author Chen, Zhiqiang
Zheng, Yi
Ji, Guanghai
Liu, Xinxin
Li, Peng
Cai, Lei
Guo, Yulin
Yang, Jian
author_facet Chen, Zhiqiang
Zheng, Yi
Ji, Guanghai
Liu, Xinxin
Li, Peng
Cai, Lei
Guo, Yulin
Yang, Jian
author_sort Chen, Zhiqiang
collection PubMed
description The goals of this meta-analysis were to assess the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with prostate carcinoma (PCa) and to explore the risk profiles with the highest benefit. Systematic electronic searched were conducted in database. We used patient-based and biopsy-based pooled weighted estimates of the sensitivity, specificity, and a summary receiver operating characteristic (SROC) curve for assessing the diagnostic performance of DCE. We performed direct and indirect comparisons of DCE and other methods of imaging. A total of 26 articles met the inclusion criteria for the analysis. DCE-MRI pooled sensitivity was 0.53 (95% CI 0.39 to 0.67), with a specificity of 0.88 (95% CI 0.83 to 0.92) on whole gland. The peripheral zone pooled sensitivity was 0.70 (95% CI 0.46 to 0.86), with a specificity of 0.88 (95% CI 0.76 to 0.94). Compared with T2-weighted imaging (T2WI), DCE was statistically superior to T2. In conclusion, DCE had relatively high specificity in detecting PCa but relatively low sensitivity as a complementary functional method. DCE-MRI might help clinicians exclude cases of normal tissue and serve as an adjunct to conventional imaging when seeking to identify tumor foci in patients with PCa.
format Online
Article
Text
id pubmed-5652829
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-56528292017-11-02 Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis Chen, Zhiqiang Zheng, Yi Ji, Guanghai Liu, Xinxin Li, Peng Cai, Lei Guo, Yulin Yang, Jian Oncotarget Meta-Analysis The goals of this meta-analysis were to assess the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with prostate carcinoma (PCa) and to explore the risk profiles with the highest benefit. Systematic electronic searched were conducted in database. We used patient-based and biopsy-based pooled weighted estimates of the sensitivity, specificity, and a summary receiver operating characteristic (SROC) curve for assessing the diagnostic performance of DCE. We performed direct and indirect comparisons of DCE and other methods of imaging. A total of 26 articles met the inclusion criteria for the analysis. DCE-MRI pooled sensitivity was 0.53 (95% CI 0.39 to 0.67), with a specificity of 0.88 (95% CI 0.83 to 0.92) on whole gland. The peripheral zone pooled sensitivity was 0.70 (95% CI 0.46 to 0.86), with a specificity of 0.88 (95% CI 0.76 to 0.94). Compared with T2-weighted imaging (T2WI), DCE was statistically superior to T2. In conclusion, DCE had relatively high specificity in detecting PCa but relatively low sensitivity as a complementary functional method. DCE-MRI might help clinicians exclude cases of normal tissue and serve as an adjunct to conventional imaging when seeking to identify tumor foci in patients with PCa. Impact Journals LLC 2017-08-17 /pmc/articles/PMC5652829/ /pubmed/29100440 http://dx.doi.org/10.18632/oncotarget.20316 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Meta-Analysis
Chen, Zhiqiang
Zheng, Yi
Ji, Guanghai
Liu, Xinxin
Li, Peng
Cai, Lei
Guo, Yulin
Yang, Jian
Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis
title Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis
title_full Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis
title_fullStr Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis
title_full_unstemmed Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis
title_short Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis
title_sort accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652829/
https://www.ncbi.nlm.nih.gov/pubmed/29100440
http://dx.doi.org/10.18632/oncotarget.20316
work_keys_str_mv AT chenzhiqiang accuracyofdynamiccontrastenhancedmagneticresonanceimaginginthediagnosisofprostatecancersystematicreviewandmetaanalysis
AT zhengyi accuracyofdynamiccontrastenhancedmagneticresonanceimaginginthediagnosisofprostatecancersystematicreviewandmetaanalysis
AT jiguanghai accuracyofdynamiccontrastenhancedmagneticresonanceimaginginthediagnosisofprostatecancersystematicreviewandmetaanalysis
AT liuxinxin accuracyofdynamiccontrastenhancedmagneticresonanceimaginginthediagnosisofprostatecancersystematicreviewandmetaanalysis
AT lipeng accuracyofdynamiccontrastenhancedmagneticresonanceimaginginthediagnosisofprostatecancersystematicreviewandmetaanalysis
AT cailei accuracyofdynamiccontrastenhancedmagneticresonanceimaginginthediagnosisofprostatecancersystematicreviewandmetaanalysis
AT guoyulin accuracyofdynamiccontrastenhancedmagneticresonanceimaginginthediagnosisofprostatecancersystematicreviewandmetaanalysis
AT yangjian accuracyofdynamiccontrastenhancedmagneticresonanceimaginginthediagnosisofprostatecancersystematicreviewandmetaanalysis