The role of substance P in epilepsy and seizure disorders

A range of evidence implicates the neuropeptide substance P (SP), a member of the tachykinin family, in emotional behavior, anxiety, pain, and inflammation. Recently, SP has been implicated in susceptibility to seizures, for which a potential proconvulsant role was indicated. Indeed, antagonists of...

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Detalles Bibliográficos
Autores principales: Wang, Xue Feng, Ge, Tong Tong, Fan, Jie, Yang, Wei, Cui, Ran Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652851/
https://www.ncbi.nlm.nih.gov/pubmed/29100462
http://dx.doi.org/10.18632/oncotarget.20606
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author Wang, Xue Feng
Ge, Tong Tong
Fan, Jie
Yang, Wei
Cui, Ran Ji
author_facet Wang, Xue Feng
Ge, Tong Tong
Fan, Jie
Yang, Wei
Cui, Ran Ji
author_sort Wang, Xue Feng
collection PubMed
description A range of evidence implicates the neuropeptide substance P (SP), a member of the tachykinin family, in emotional behavior, anxiety, pain, and inflammation. Recently, SP has been implicated in susceptibility to seizures, for which a potential proconvulsant role was indicated. Indeed, antagonists of a specific SP receptor, neurokinin-1 receptor, were found to attenuate kainic acid (KA)-induced seizure activity. However, detailed mechanisms of SP regulation in epilepsy remain obscure. In this review, we summarize the present literature to expound the role of SP in epilepsy, and provide hypotheses for potential mechanisms.
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spelling pubmed-56528512017-11-02 The role of substance P in epilepsy and seizure disorders Wang, Xue Feng Ge, Tong Tong Fan, Jie Yang, Wei Cui, Ran Ji Oncotarget Review A range of evidence implicates the neuropeptide substance P (SP), a member of the tachykinin family, in emotional behavior, anxiety, pain, and inflammation. Recently, SP has been implicated in susceptibility to seizures, for which a potential proconvulsant role was indicated. Indeed, antagonists of a specific SP receptor, neurokinin-1 receptor, were found to attenuate kainic acid (KA)-induced seizure activity. However, detailed mechanisms of SP regulation in epilepsy remain obscure. In this review, we summarize the present literature to expound the role of SP in epilepsy, and provide hypotheses for potential mechanisms. Impact Journals LLC 2017-09-01 /pmc/articles/PMC5652851/ /pubmed/29100462 http://dx.doi.org/10.18632/oncotarget.20606 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Wang, Xue Feng
Ge, Tong Tong
Fan, Jie
Yang, Wei
Cui, Ran Ji
The role of substance P in epilepsy and seizure disorders
title The role of substance P in epilepsy and seizure disorders
title_full The role of substance P in epilepsy and seizure disorders
title_fullStr The role of substance P in epilepsy and seizure disorders
title_full_unstemmed The role of substance P in epilepsy and seizure disorders
title_short The role of substance P in epilepsy and seizure disorders
title_sort role of substance p in epilepsy and seizure disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652851/
https://www.ncbi.nlm.nih.gov/pubmed/29100462
http://dx.doi.org/10.18632/oncotarget.20606
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