Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin) focuses and insulates termination of local second messenger responses. Conformational flexibility in regions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B access to phosphoproteins....

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Detalles Bibliográficos
Autores principales: Nygren, Patrick J, Mehta, Sohum, Schweppe, Devin K, Langeberg, Lorene K, Whiting, Jennifer L, Weisbrod, Chad R, Bruce, James E, Zhang, Jin, Veesler, David, Scott, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653234/
https://www.ncbi.nlm.nih.gov/pubmed/28967377
http://dx.doi.org/10.7554/eLife.30872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653234/
https://www.ncbi.nlm.nih.gov/pubmed/28967377
http://dx.doi.org/10.7554/eLife.30872

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