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Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review

BACKGROUND: Insomnia disorder is a widespread sleep disorder with a prevalence of approximately 10%. Even though the link between insomnia and cardiovascular activity is not exactly clear, it is generally assumed that cardiovascular autonomic modifications could occur as a result of sleeplessness, o...

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Autores principales: Nano, Marina-Marinela, Fonseca, Pedro, Vullings, Rik, Aarts, Ronald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653329/
https://www.ncbi.nlm.nih.gov/pubmed/29059210
http://dx.doi.org/10.1371/journal.pone.0186716
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author Nano, Marina-Marinela
Fonseca, Pedro
Vullings, Rik
Aarts, Ronald M.
author_facet Nano, Marina-Marinela
Fonseca, Pedro
Vullings, Rik
Aarts, Ronald M.
author_sort Nano, Marina-Marinela
collection PubMed
description BACKGROUND: Insomnia disorder is a widespread sleep disorder with a prevalence of approximately 10%. Even though the link between insomnia and cardiovascular activity is not exactly clear, it is generally assumed that cardiovascular autonomic modifications could occur as a result of sleeplessness, or, alternatively, that autonomic alterations could be an expression of a hyper-arousal state. This review investigates whether cardiovascular measures are different between insomniacs and controls. METHODS: Electronic databases were systematically searched, and 34 studies were identified. Heart rate variability features, the association of cardiac and EEG activity, physiologic complexity measures, and cardiovascular activity, assessed by measures such as pre-ejection time, blood pressure, and heart rate dynamics were studied. Given the heterogeneity of the studies, a narrative synthesis of the findings was performed. RESULTS: This review study found overall differences in cardiovascular activity between insomniacs and controls in most of the observational studies (21/26), while the expression of cardiovascular regulation varied between the examined insomniac groups. All the studies that investigated the association of cardiac activity and EEG power reported an altered relation between autonomic activity and EEG parameters in insomniacs. CONCLUSION: Autonomic regulation tends to be consistent between insomniacs, as long as they are grouped according to their respective phenotype, as shown in the insomnia subgroup with objectively short sleep duration. Our hypothesis is that these differences in the expression of cardiovascular activity could be explained by the heterogeneity of the disorder. Therefore, the determination of insomnia phenotypes, and the study of cardiovascular measures, rather than heart rate variability alone, will give more insight into the link between insomnia and cardiovascular regulation. This study suggests that cardiovascular activity differs between insomniacs and controls. These new findings are of interest to clinicians and researchers for a more accurate insomnia assessment, and the development of personalized technological solutions in insomnia.
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spelling pubmed-56533292017-11-08 Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review Nano, Marina-Marinela Fonseca, Pedro Vullings, Rik Aarts, Ronald M. PLoS One Research Article BACKGROUND: Insomnia disorder is a widespread sleep disorder with a prevalence of approximately 10%. Even though the link between insomnia and cardiovascular activity is not exactly clear, it is generally assumed that cardiovascular autonomic modifications could occur as a result of sleeplessness, or, alternatively, that autonomic alterations could be an expression of a hyper-arousal state. This review investigates whether cardiovascular measures are different between insomniacs and controls. METHODS: Electronic databases were systematically searched, and 34 studies were identified. Heart rate variability features, the association of cardiac and EEG activity, physiologic complexity measures, and cardiovascular activity, assessed by measures such as pre-ejection time, blood pressure, and heart rate dynamics were studied. Given the heterogeneity of the studies, a narrative synthesis of the findings was performed. RESULTS: This review study found overall differences in cardiovascular activity between insomniacs and controls in most of the observational studies (21/26), while the expression of cardiovascular regulation varied between the examined insomniac groups. All the studies that investigated the association of cardiac activity and EEG power reported an altered relation between autonomic activity and EEG parameters in insomniacs. CONCLUSION: Autonomic regulation tends to be consistent between insomniacs, as long as they are grouped according to their respective phenotype, as shown in the insomnia subgroup with objectively short sleep duration. Our hypothesis is that these differences in the expression of cardiovascular activity could be explained by the heterogeneity of the disorder. Therefore, the determination of insomnia phenotypes, and the study of cardiovascular measures, rather than heart rate variability alone, will give more insight into the link between insomnia and cardiovascular regulation. This study suggests that cardiovascular activity differs between insomniacs and controls. These new findings are of interest to clinicians and researchers for a more accurate insomnia assessment, and the development of personalized technological solutions in insomnia. Public Library of Science 2017-10-23 /pmc/articles/PMC5653329/ /pubmed/29059210 http://dx.doi.org/10.1371/journal.pone.0186716 Text en © 2017 Nano et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nano, Marina-Marinela
Fonseca, Pedro
Vullings, Rik
Aarts, Ronald M.
Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review
title Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review
title_full Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review
title_fullStr Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review
title_full_unstemmed Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review
title_short Measures of cardiovascular autonomic activity in insomnia disorder: A systematic review
title_sort measures of cardiovascular autonomic activity in insomnia disorder: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653329/
https://www.ncbi.nlm.nih.gov/pubmed/29059210
http://dx.doi.org/10.1371/journal.pone.0186716
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