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Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea
BACKGROUND AND PURPOSE: Falling with a femur fracture is a serious event that negatively affects the quality of life of elderly individuals as well as patients with parkinsonism. This study investigated the association between parkinsonism and femur fracture and compared the risk of femur fracture b...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurological Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653626/ https://www.ncbi.nlm.nih.gov/pubmed/29057630 http://dx.doi.org/10.3988/jcn.2017.13.4.380 |
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author | An, Soo Jeong Lee, Seung-Hwan Lee, Seo-Young Kwon, Jae-Woo Lee, Seung-Joon Kim, Young-Ju |
author_facet | An, Soo Jeong Lee, Seung-Hwan Lee, Seo-Young Kwon, Jae-Woo Lee, Seung-Joon Kim, Young-Ju |
author_sort | An, Soo Jeong |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Falling with a femur fracture is a serious event that negatively affects the quality of life of elderly individuals as well as patients with parkinsonism. This study investigated the association between parkinsonism and femur fracture and compared the risk of femur fracture between subjects with and without parkinsonism. METHODS: This study examined a population-based matched cohort constructed using the National Sample Cohort data set, which comprises approximately one million subscribers to medical insurance and aid in South Korea. Subjects with parkinsonism during 2003–2013 were identified as the exposed group, and up to five individuals matched for age, sex, and index years were identified as the controls for each parkinsonism subject. The risk of femur fracture for parkinsonism was evaluated using Cox regression. RESULTS: The incidence of femur fracture according to age, sex, and body mass index varied significantly between subjects with parkinsonism and controls (p<0.001). The presence of parkinsonism was associated with a higher risk of femur fractures for males [hazard ratio (HR)=2.85, 95% confidence interval [CI]=1.87–4.34], subjects younger than 65 years (HR=2.89, 95% CI=1.64–5.11), and underweight subjects (HR=3.90, 95% CI=1.82–8.35). The adjusted HR for femur fracture with parkinsonism was highest within 2 years of the disease diagnosis (HR=3.10, 95% CI=2.12–4.53). CONCLUSIONS: Our study found that the presence of parkinsonism is more strongly related to femur fracture in males, and increases the influence of traditional risk factors on femur fracture. It is necessary to consider how factors associated with the amount of ambulatory activity–even in an early diagnosed state–can play an important role in femur fracture in subjects with parkinsonism. |
format | Online Article Text |
id | pubmed-5653626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-56536262017-10-24 Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea An, Soo Jeong Lee, Seung-Hwan Lee, Seo-Young Kwon, Jae-Woo Lee, Seung-Joon Kim, Young-Ju J Clin Neurol Original Article BACKGROUND AND PURPOSE: Falling with a femur fracture is a serious event that negatively affects the quality of life of elderly individuals as well as patients with parkinsonism. This study investigated the association between parkinsonism and femur fracture and compared the risk of femur fracture between subjects with and without parkinsonism. METHODS: This study examined a population-based matched cohort constructed using the National Sample Cohort data set, which comprises approximately one million subscribers to medical insurance and aid in South Korea. Subjects with parkinsonism during 2003–2013 were identified as the exposed group, and up to five individuals matched for age, sex, and index years were identified as the controls for each parkinsonism subject. The risk of femur fracture for parkinsonism was evaluated using Cox regression. RESULTS: The incidence of femur fracture according to age, sex, and body mass index varied significantly between subjects with parkinsonism and controls (p<0.001). The presence of parkinsonism was associated with a higher risk of femur fractures for males [hazard ratio (HR)=2.85, 95% confidence interval [CI]=1.87–4.34], subjects younger than 65 years (HR=2.89, 95% CI=1.64–5.11), and underweight subjects (HR=3.90, 95% CI=1.82–8.35). The adjusted HR for femur fracture with parkinsonism was highest within 2 years of the disease diagnosis (HR=3.10, 95% CI=2.12–4.53). CONCLUSIONS: Our study found that the presence of parkinsonism is more strongly related to femur fracture in males, and increases the influence of traditional risk factors on femur fracture. It is necessary to consider how factors associated with the amount of ambulatory activity–even in an early diagnosed state–can play an important role in femur fracture in subjects with parkinsonism. Korean Neurological Association 2017-10 2017-09-27 /pmc/articles/PMC5653626/ /pubmed/29057630 http://dx.doi.org/10.3988/jcn.2017.13.4.380 Text en Copyright © 2017 Korean Neurological Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article An, Soo Jeong Lee, Seung-Hwan Lee, Seo-Young Kwon, Jae-Woo Lee, Seung-Joon Kim, Young-Ju Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea |
title | Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea |
title_full | Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea |
title_fullStr | Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea |
title_full_unstemmed | Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea |
title_short | Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea |
title_sort | femur fractures in parkinsonism: analysis of a national sample cohort in south korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653626/ https://www.ncbi.nlm.nih.gov/pubmed/29057630 http://dx.doi.org/10.3988/jcn.2017.13.4.380 |
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