αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis

Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRβ) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFRβ(+) cells contribute to skeletal muscle and cardiac fibrosis via a mechanism that depends on αv integrins. Mice in...

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Detalles Bibliográficos
Autores principales: Murray, I. R., Gonzalez, Z. N., Baily, J., Dobie, R., Wallace, R. J., Mackinnon, A. C., Smith, J. R., Greenhalgh, S. N., Thompson, A. I., Conroy, K. P., Griggs, D. W., Ruminski, P. G., Gray, G. A., Singh, M., Campbell, M. A., Kendall, T. J., Dai, J., Li, Y., Iredale, J. P., Simpson, H., Huard, J., Péault, B., Henderson, N. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653645/
https://www.ncbi.nlm.nih.gov/pubmed/29061963
http://dx.doi.org/10.1038/s41467-017-01097-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653645/
https://www.ncbi.nlm.nih.gov/pubmed/29061963
http://dx.doi.org/10.1038/s41467-017-01097-z

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