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Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems
ABSTRACT: Cytochrome P450 (CYP) 1A1 is the most important enzyme activating and detoxifying the human carcinogen benzo[a]pyrene (BaP). In the previous studies, we had shown that not only the canonic NADPH:CYP oxidoreductase (POR) can act as electron donor but also cytochrome b (5) and its reductase,...
Autores principales: | Stiborová, Marie, Indra, Radek, Moserová, Michaela, Bořek-Dohalská, Lucie, Hodek, Petr, Frei, Eva, Kopka, Klaus, Schmeiser, Heinz H., Arlt, Volker M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653725/ https://www.ncbi.nlm.nih.gov/pubmed/29104317 http://dx.doi.org/10.1007/s00706-017-2002-0 |
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