Identification of a Different Agonist-Binding Site and Activation Mechanism of the Human P2Y(1) Receptor

The human P2Y(1) receptor (P2Y(1)R) is a purinergic G-protein-coupled receptor (GPCR) that functions as a receptor for adenosine 5′-diphosphate (ADP). An antagonist of P2Y(1)R might potentially have antithrombotic effects, whereas agonists might serve as antidiabetic agents. On the basis of the anta...

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Detalles Bibliográficos
Autores principales: Li, Yang, Yin, Can, Liu, Pi, Li, Dongmei, Lin, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653743/
https://www.ncbi.nlm.nih.gov/pubmed/29062134
http://dx.doi.org/10.1038/s41598-017-14268-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653743/
https://www.ncbi.nlm.nih.gov/pubmed/29062134
http://dx.doi.org/10.1038/s41598-017-14268-1

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