Cytochrome b(5) plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine

ABSTRACT: Ellipticine is an anticancer agent that forms covalent DNA adducts after enzymatic activation by cytochrome P450 (CYP) enzymes, mainly by CYP3A4. This process is one of the most important ellipticine DNA-damaging mechanisms for its antitumor action. Here, we investigated the efficiencies o...

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Detalles Bibliográficos
Autores principales: Stiborová, Marie, Indra, Radek, Frei, Eva, Kopečková, Kateřina, Schmeiser, Heinz H., Eckschlager, Tomáš, Adam, Vojtěch, Heger, Zbyněk, Arlt, Volker M., Martínek, Václav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653753/
https://www.ncbi.nlm.nih.gov/pubmed/29104319
http://dx.doi.org/10.1007/s00706-017-1986-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653753/
https://www.ncbi.nlm.nih.gov/pubmed/29104319
http://dx.doi.org/10.1007/s00706-017-1986-9

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