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CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease

In Alzheimer’s disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanis...

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Detalles Bibliográficos
Autores principales:	Koch, Giacomo, Di Lorenzo, Francesco, Loizzo, Stefano, Motta, Caterina, Travaglione, Sara, Baiula, Monica, Rimondini, Roberto, Ponzo, Viviana, Bonnì, Sonia, Toniolo, Sofia, Sallustio, Fabrizio, Bozzali, Marco, Caltagirone, Carlo, Campana, Gabriele, Martorana, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653826/ https://www.ncbi.nlm.nih.gov/pubmed/29062035 http://dx.doi.org/10.1038/s41598-017-14204-3

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