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Region and species dependent mechanical properties of adolescent and young adult brain tissue

Traumatic brain injuries, the leading cause of death and disability in children and young adults, are the result of a rapid acceleration or impact of the head. In recent years, a global effort to better understand the biomechanics of TBI has been undertaken, with many laboratories creating detailed...

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Autores principales: MacManus, David B., Pierrat, Baptiste, Murphy, Jeremiah G., Gilchrist, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653834/
https://www.ncbi.nlm.nih.gov/pubmed/29061984
http://dx.doi.org/10.1038/s41598-017-13727-z
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author MacManus, David B.
Pierrat, Baptiste
Murphy, Jeremiah G.
Gilchrist, Michael D.
author_facet MacManus, David B.
Pierrat, Baptiste
Murphy, Jeremiah G.
Gilchrist, Michael D.
author_sort MacManus, David B.
collection PubMed
description Traumatic brain injuries, the leading cause of death and disability in children and young adults, are the result of a rapid acceleration or impact of the head. In recent years, a global effort to better understand the biomechanics of TBI has been undertaken, with many laboratories creating detailed computational models of the head and brain. For these models to produce realistic results they require accurate regional constitutive data for brain tissue. However, there are large differences in the mechanical properties reported in the literature. These differences are likely due to experimental parameters such as specimen age, brain region, species, test protocols, and fiber direction which are often not reported. Furthermore, there is a dearth of reported viscoelastic properties for brain tissue at large-strain and high rates. Mouse, rat, and pig brains are impacted at 10/s to a strain of ~36% using a custom-built micro-indenter with a 125 μm radius. It is shown that the resultant mechanical properties are dependent on specimen-age, species, and region, under identical experimental parameters.
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spelling pubmed-56538342017-11-08 Region and species dependent mechanical properties of adolescent and young adult brain tissue MacManus, David B. Pierrat, Baptiste Murphy, Jeremiah G. Gilchrist, Michael D. Sci Rep Article Traumatic brain injuries, the leading cause of death and disability in children and young adults, are the result of a rapid acceleration or impact of the head. In recent years, a global effort to better understand the biomechanics of TBI has been undertaken, with many laboratories creating detailed computational models of the head and brain. For these models to produce realistic results they require accurate regional constitutive data for brain tissue. However, there are large differences in the mechanical properties reported in the literature. These differences are likely due to experimental parameters such as specimen age, brain region, species, test protocols, and fiber direction which are often not reported. Furthermore, there is a dearth of reported viscoelastic properties for brain tissue at large-strain and high rates. Mouse, rat, and pig brains are impacted at 10/s to a strain of ~36% using a custom-built micro-indenter with a 125 μm radius. It is shown that the resultant mechanical properties are dependent on specimen-age, species, and region, under identical experimental parameters. Nature Publishing Group UK 2017-10-23 /pmc/articles/PMC5653834/ /pubmed/29061984 http://dx.doi.org/10.1038/s41598-017-13727-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
MacManus, David B.
Pierrat, Baptiste
Murphy, Jeremiah G.
Gilchrist, Michael D.
Region and species dependent mechanical properties of adolescent and young adult brain tissue
title Region and species dependent mechanical properties of adolescent and young adult brain tissue
title_full Region and species dependent mechanical properties of adolescent and young adult brain tissue
title_fullStr Region and species dependent mechanical properties of adolescent and young adult brain tissue
title_full_unstemmed Region and species dependent mechanical properties of adolescent and young adult brain tissue
title_short Region and species dependent mechanical properties of adolescent and young adult brain tissue
title_sort region and species dependent mechanical properties of adolescent and young adult brain tissue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653834/
https://www.ncbi.nlm.nih.gov/pubmed/29061984
http://dx.doi.org/10.1038/s41598-017-13727-z
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