Cargando…
Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons
Electrical stimulation is an important tool in neuroscience research and clinically. In the retina, extensive work has revealed how the retinal ganglion cells respond to extracellular electrical stimulation. But little is known about the responses of other neuronal types, and more generally, how the...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653866/ https://www.ncbi.nlm.nih.gov/pubmed/29062068 http://dx.doi.org/10.1038/s41598-017-14357-1 |
_version_ | 1783273294993031168 |
---|---|
author | Tsai, David Morley, John W. Suaning, Gregg J. Lovell, Nigel H. |
author_facet | Tsai, David Morley, John W. Suaning, Gregg J. Lovell, Nigel H. |
author_sort | Tsai, David |
collection | PubMed |
description | Electrical stimulation is an important tool in neuroscience research and clinically. In the retina, extensive work has revealed how the retinal ganglion cells respond to extracellular electrical stimulation. But little is known about the responses of other neuronal types, and more generally, how the network responds to stimulation. We conducted a survey of electrically evoked responses, over a range of pulse amplitudes and pulse widths, for 21 cell types spanning the inner two layers of the rabbit retina. It revealed: (i) the evoked responses of some neurons were charge insensitive; (ii) pulse-width sensitivity varied between cell types, allowing preferential recruitment of cell types; and (iii) 10–20 Hz damped oscillations across retinal layers. These oscillations were generated by reciprocal excitatory / inhibitory synapses, at locations as early as the cone-horizontal-cell synapses. These results illustrate at cellular resolution how a network responds to extracellular stimulation, and could inform the development of bioelectronic implants for treating blindness. |
format | Online Article Text |
id | pubmed-5653866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56538662017-11-08 Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons Tsai, David Morley, John W. Suaning, Gregg J. Lovell, Nigel H. Sci Rep Article Electrical stimulation is an important tool in neuroscience research and clinically. In the retina, extensive work has revealed how the retinal ganglion cells respond to extracellular electrical stimulation. But little is known about the responses of other neuronal types, and more generally, how the network responds to stimulation. We conducted a survey of electrically evoked responses, over a range of pulse amplitudes and pulse widths, for 21 cell types spanning the inner two layers of the rabbit retina. It revealed: (i) the evoked responses of some neurons were charge insensitive; (ii) pulse-width sensitivity varied between cell types, allowing preferential recruitment of cell types; and (iii) 10–20 Hz damped oscillations across retinal layers. These oscillations were generated by reciprocal excitatory / inhibitory synapses, at locations as early as the cone-horizontal-cell synapses. These results illustrate at cellular resolution how a network responds to extracellular stimulation, and could inform the development of bioelectronic implants for treating blindness. Nature Publishing Group UK 2017-10-23 /pmc/articles/PMC5653866/ /pubmed/29062068 http://dx.doi.org/10.1038/s41598-017-14357-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Tsai, David Morley, John W. Suaning, Gregg J. Lovell, Nigel H. Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons |
title | Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons |
title_full | Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons |
title_fullStr | Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons |
title_full_unstemmed | Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons |
title_short | Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons |
title_sort | survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653866/ https://www.ncbi.nlm.nih.gov/pubmed/29062068 http://dx.doi.org/10.1038/s41598-017-14357-1 |
work_keys_str_mv | AT tsaidavid surveyofelectricallyevokedresponsesintheretinastimuluspreferencesandoscillationamongneurons AT morleyjohnw surveyofelectricallyevokedresponsesintheretinastimuluspreferencesandoscillationamongneurons AT suaninggreggj surveyofelectricallyevokedresponsesintheretinastimuluspreferencesandoscillationamongneurons AT lovellnigelh surveyofelectricallyevokedresponsesintheretinastimuluspreferencesandoscillationamongneurons |