NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins

BACKGROUND: The major human fungal pathogen Candida albicans possesses a diploid genome, but responds to growth in challenging environments by employing chromosome aneuploidy as an adaptation mechanism. For example, we have shown that C. albicans adapts to growth on the toxic sugar l-sorbose by tran...

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Detalles Bibliográficos
Autores principales: Wakabayashi, Hironao, Tucker, Christopher, Bethlendy, Gabor, Kravets, Anatoliy, Welle, Stephen L., Bulger, Michael, Hayes, Jeffrey, Rustchenko, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653997/
https://www.ncbi.nlm.nih.gov/pubmed/29061172
http://dx.doi.org/10.1186/s13072-017-0156-y

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