Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients

BACKGROUND: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still remain unknown. Here, we report our findings fro...

Descripción completa

Detalles Bibliográficos
Autores principales: Chondrou, Vasiliki, Kolovos, Petros, Sgourou, Argyro, Kourakli, Alexandra, Pavlidaki, Alexia, Kastrinou, Vlasia, John, Anne, Symeonidis, Argiris, Ali, Bassam R., Papachatzopoulou, Adamantia, Katsila, Theodora, Patrinos, George P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654038/
https://www.ncbi.nlm.nih.gov/pubmed/29061162
http://dx.doi.org/10.1186/s40246-017-0120-8

Ejemplares similares

Ejemplares similares