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Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience
PURPOSE: The optimal adjuvant therapy modality for treating pN2 non-small cell lung cancer patients has not yet been established. In this study, the authors investigated clinical outcomes following three different adjuvant therapy modalities. MATERIALS AND METHODS: From January 2006 to December 2012...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654153/ https://www.ncbi.nlm.nih.gov/pubmed/28052657 http://dx.doi.org/10.4143/crt.2016.442 |
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author | Park, Hyojung Oh, Dongryul Ahn, Yong Chan Pyo, Hongryull Noh, Jae Myung Sun, Jong-Mu Ahn, Jin Seok Ahn, Myung-Ju Park, Keunchil Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Zo, Jae Ill Shim, Young Mog |
author_facet | Park, Hyojung Oh, Dongryul Ahn, Yong Chan Pyo, Hongryull Noh, Jae Myung Sun, Jong-Mu Ahn, Jin Seok Ahn, Myung-Ju Park, Keunchil Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Zo, Jae Ill Shim, Young Mog |
author_sort | Park, Hyojung |
collection | PubMed |
description | PURPOSE: The optimal adjuvant therapy modality for treating pN2 non-small cell lung cancer patients has not yet been established. In this study, the authors investigated clinical outcomes following three different adjuvant therapy modalities. MATERIALS AND METHODS: From January 2006 to December 2012, 240 patients with cN0/1 disease were found to have pN2 disease following curative resection and received one of three adjuvant therapy modalities:thoracic radiation therapy (TRT) and concurrent chemotherapy (CTx) (CCRT) (group I), CCRT plus consolidation CTx (group II), and CTx alone (group III). TRT was delivered to 155 patients (groups I/II), and full dose CTx was delivered to 172 patients either as a consolidative or a sole modality (group II/III). RESULTS: During 30 months of median follow-up, 44 patients died and 141 developed recurrence. The 5-year overall survival (OS), locoregional control (LRC), distant metastasis-free survival (DMFS), and disease-free survival (DFS) rates of all patients were 76.2%, 80.7%, 36.4%, and 29.6%, respectively. There was no difference in OS among groups. TRT (groups I/II) significantly improved LRC, full dose CTx (groups II/III) did DMFS, and CCRT plus consolidation CTx (group II) did DFS, respectively. CONCLUSION: The current study could support that TRT could improve LRC and full dose CTx could improve DMFS and that CCRT plus consolidation CTx could improve DFS. |
format | Online Article Text |
id | pubmed-5654153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-56541532017-10-25 Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience Park, Hyojung Oh, Dongryul Ahn, Yong Chan Pyo, Hongryull Noh, Jae Myung Sun, Jong-Mu Ahn, Jin Seok Ahn, Myung-Ju Park, Keunchil Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Zo, Jae Ill Shim, Young Mog Cancer Res Treat Original Article PURPOSE: The optimal adjuvant therapy modality for treating pN2 non-small cell lung cancer patients has not yet been established. In this study, the authors investigated clinical outcomes following three different adjuvant therapy modalities. MATERIALS AND METHODS: From January 2006 to December 2012, 240 patients with cN0/1 disease were found to have pN2 disease following curative resection and received one of three adjuvant therapy modalities:thoracic radiation therapy (TRT) and concurrent chemotherapy (CTx) (CCRT) (group I), CCRT plus consolidation CTx (group II), and CTx alone (group III). TRT was delivered to 155 patients (groups I/II), and full dose CTx was delivered to 172 patients either as a consolidative or a sole modality (group II/III). RESULTS: During 30 months of median follow-up, 44 patients died and 141 developed recurrence. The 5-year overall survival (OS), locoregional control (LRC), distant metastasis-free survival (DMFS), and disease-free survival (DFS) rates of all patients were 76.2%, 80.7%, 36.4%, and 29.6%, respectively. There was no difference in OS among groups. TRT (groups I/II) significantly improved LRC, full dose CTx (groups II/III) did DMFS, and CCRT plus consolidation CTx (group II) did DFS, respectively. CONCLUSION: The current study could support that TRT could improve LRC and full dose CTx could improve DMFS and that CCRT plus consolidation CTx could improve DFS. Korean Cancer Association 2017-10 2016-12-12 /pmc/articles/PMC5654153/ /pubmed/28052657 http://dx.doi.org/10.4143/crt.2016.442 Text en Copyright © 2017 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Hyojung Oh, Dongryul Ahn, Yong Chan Pyo, Hongryull Noh, Jae Myung Sun, Jong-Mu Ahn, Jin Seok Ahn, Myung-Ju Park, Keunchil Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Zo, Jae Ill Shim, Young Mog Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience |
title | Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience |
title_full | Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience |
title_fullStr | Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience |
title_full_unstemmed | Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience |
title_short | Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience |
title_sort | role of adjuvant thoracic radiation therapy and full dose chemotherapy in pn2 non-small cell lung cancer: elucidation based on single institute experience |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654153/ https://www.ncbi.nlm.nih.gov/pubmed/28052657 http://dx.doi.org/10.4143/crt.2016.442 |
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