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Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience

PURPOSE: The optimal adjuvant therapy modality for treating pN2 non-small cell lung cancer patients has not yet been established. In this study, the authors investigated clinical outcomes following three different adjuvant therapy modalities. MATERIALS AND METHODS: From January 2006 to December 2012...

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Autores principales: Park, Hyojung, Oh, Dongryul, Ahn, Yong Chan, Pyo, Hongryull, Noh, Jae Myung, Sun, Jong-Mu, Ahn, Jin Seok, Ahn, Myung-Ju, Park, Keunchil, Kim, Hong Kwan, Choi, Yong Soo, Kim, Jhingook, Zo, Jae Ill, Shim, Young Mog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654153/
https://www.ncbi.nlm.nih.gov/pubmed/28052657
http://dx.doi.org/10.4143/crt.2016.442
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author Park, Hyojung
Oh, Dongryul
Ahn, Yong Chan
Pyo, Hongryull
Noh, Jae Myung
Sun, Jong-Mu
Ahn, Jin Seok
Ahn, Myung-Ju
Park, Keunchil
Kim, Hong Kwan
Choi, Yong Soo
Kim, Jhingook
Zo, Jae Ill
Shim, Young Mog
author_facet Park, Hyojung
Oh, Dongryul
Ahn, Yong Chan
Pyo, Hongryull
Noh, Jae Myung
Sun, Jong-Mu
Ahn, Jin Seok
Ahn, Myung-Ju
Park, Keunchil
Kim, Hong Kwan
Choi, Yong Soo
Kim, Jhingook
Zo, Jae Ill
Shim, Young Mog
author_sort Park, Hyojung
collection PubMed
description PURPOSE: The optimal adjuvant therapy modality for treating pN2 non-small cell lung cancer patients has not yet been established. In this study, the authors investigated clinical outcomes following three different adjuvant therapy modalities. MATERIALS AND METHODS: From January 2006 to December 2012, 240 patients with cN0/1 disease were found to have pN2 disease following curative resection and received one of three adjuvant therapy modalities:thoracic radiation therapy (TRT) and concurrent chemotherapy (CTx) (CCRT) (group I), CCRT plus consolidation CTx (group II), and CTx alone (group III). TRT was delivered to 155 patients (groups I/II), and full dose CTx was delivered to 172 patients either as a consolidative or a sole modality (group II/III). RESULTS: During 30 months of median follow-up, 44 patients died and 141 developed recurrence. The 5-year overall survival (OS), locoregional control (LRC), distant metastasis-free survival (DMFS), and disease-free survival (DFS) rates of all patients were 76.2%, 80.7%, 36.4%, and 29.6%, respectively. There was no difference in OS among groups. TRT (groups I/II) significantly improved LRC, full dose CTx (groups II/III) did DMFS, and CCRT plus consolidation CTx (group II) did DFS, respectively. CONCLUSION: The current study could support that TRT could improve LRC and full dose CTx could improve DMFS and that CCRT plus consolidation CTx could improve DFS.
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spelling pubmed-56541532017-10-25 Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience Park, Hyojung Oh, Dongryul Ahn, Yong Chan Pyo, Hongryull Noh, Jae Myung Sun, Jong-Mu Ahn, Jin Seok Ahn, Myung-Ju Park, Keunchil Kim, Hong Kwan Choi, Yong Soo Kim, Jhingook Zo, Jae Ill Shim, Young Mog Cancer Res Treat Original Article PURPOSE: The optimal adjuvant therapy modality for treating pN2 non-small cell lung cancer patients has not yet been established. In this study, the authors investigated clinical outcomes following three different adjuvant therapy modalities. MATERIALS AND METHODS: From January 2006 to December 2012, 240 patients with cN0/1 disease were found to have pN2 disease following curative resection and received one of three adjuvant therapy modalities:thoracic radiation therapy (TRT) and concurrent chemotherapy (CTx) (CCRT) (group I), CCRT plus consolidation CTx (group II), and CTx alone (group III). TRT was delivered to 155 patients (groups I/II), and full dose CTx was delivered to 172 patients either as a consolidative or a sole modality (group II/III). RESULTS: During 30 months of median follow-up, 44 patients died and 141 developed recurrence. The 5-year overall survival (OS), locoregional control (LRC), distant metastasis-free survival (DMFS), and disease-free survival (DFS) rates of all patients were 76.2%, 80.7%, 36.4%, and 29.6%, respectively. There was no difference in OS among groups. TRT (groups I/II) significantly improved LRC, full dose CTx (groups II/III) did DMFS, and CCRT plus consolidation CTx (group II) did DFS, respectively. CONCLUSION: The current study could support that TRT could improve LRC and full dose CTx could improve DMFS and that CCRT plus consolidation CTx could improve DFS. Korean Cancer Association 2017-10 2016-12-12 /pmc/articles/PMC5654153/ /pubmed/28052657 http://dx.doi.org/10.4143/crt.2016.442 Text en Copyright © 2017 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Hyojung
Oh, Dongryul
Ahn, Yong Chan
Pyo, Hongryull
Noh, Jae Myung
Sun, Jong-Mu
Ahn, Jin Seok
Ahn, Myung-Ju
Park, Keunchil
Kim, Hong Kwan
Choi, Yong Soo
Kim, Jhingook
Zo, Jae Ill
Shim, Young Mog
Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience
title Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience
title_full Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience
title_fullStr Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience
title_full_unstemmed Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience
title_short Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience
title_sort role of adjuvant thoracic radiation therapy and full dose chemotherapy in pn2 non-small cell lung cancer: elucidation based on single institute experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654153/
https://www.ncbi.nlm.nih.gov/pubmed/28052657
http://dx.doi.org/10.4143/crt.2016.442
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