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Cancer Chemopreventive Potential of Procyanidin

Chemoprevention entails the use of synthetic agents or naturally occurring dietary phytochemicals to prevent cancer development and progression. One promising chemopreventive agent, procyanidin, is a naturally occurring polyphenol that exhibits beneficial health effects including anti-inflammatory,...

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Autor principal: Lee, Yongkyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Toxicology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654195/
https://www.ncbi.nlm.nih.gov/pubmed/29071011
http://dx.doi.org/10.5487/TR.2017.33.4.273
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author Lee, Yongkyu
author_facet Lee, Yongkyu
author_sort Lee, Yongkyu
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description Chemoprevention entails the use of synthetic agents or naturally occurring dietary phytochemicals to prevent cancer development and progression. One promising chemopreventive agent, procyanidin, is a naturally occurring polyphenol that exhibits beneficial health effects including anti-inflammatory, antiproliferative, and antitumor activities. Currently, many preclinical reports suggest procyanidin as a promising lead compound for cancer prevention and treatment. As a potential anticancer agent, procyanidin has been shown to inhibit the proliferation of various cancer cells in “in vitro and in vivo”. Procyanidin has numerous targets, many of which are components of intracellular signaling pathways, including proinflammatory mediators, regulators of cell survival and apoptosis, and angiogenic and metastatic mediators, and modulates a set of upstream kinases, transcription factors, and their regulators. Although remarkable progress characterizing the molecular mechanisms and targets underlying the anticancer properties of procyanidin has been made in the past decade, the chemopreventive targets or biomarkers of procyanidin action have not been completely elucidated. This review focuses on the apoptosis and tumor inhibitory effects of procyanidin with respect to its bioavailability.
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spelling pubmed-56541952017-10-25 Cancer Chemopreventive Potential of Procyanidin Lee, Yongkyu Toxicol Res Review Article Chemoprevention entails the use of synthetic agents or naturally occurring dietary phytochemicals to prevent cancer development and progression. One promising chemopreventive agent, procyanidin, is a naturally occurring polyphenol that exhibits beneficial health effects including anti-inflammatory, antiproliferative, and antitumor activities. Currently, many preclinical reports suggest procyanidin as a promising lead compound for cancer prevention and treatment. As a potential anticancer agent, procyanidin has been shown to inhibit the proliferation of various cancer cells in “in vitro and in vivo”. Procyanidin has numerous targets, many of which are components of intracellular signaling pathways, including proinflammatory mediators, regulators of cell survival and apoptosis, and angiogenic and metastatic mediators, and modulates a set of upstream kinases, transcription factors, and their regulators. Although remarkable progress characterizing the molecular mechanisms and targets underlying the anticancer properties of procyanidin has been made in the past decade, the chemopreventive targets or biomarkers of procyanidin action have not been completely elucidated. This review focuses on the apoptosis and tumor inhibitory effects of procyanidin with respect to its bioavailability. Korean Society of Toxicology 2017-10 2015-10-15 /pmc/articles/PMC5654195/ /pubmed/29071011 http://dx.doi.org/10.5487/TR.2017.33.4.273 Text en Copyright © 2017 The Korean Society Of Toxicology http://creativecommons.org/licenses/by-nc/3.0 This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Yongkyu
Cancer Chemopreventive Potential of Procyanidin
title Cancer Chemopreventive Potential of Procyanidin
title_full Cancer Chemopreventive Potential of Procyanidin
title_fullStr Cancer Chemopreventive Potential of Procyanidin
title_full_unstemmed Cancer Chemopreventive Potential of Procyanidin
title_short Cancer Chemopreventive Potential of Procyanidin
title_sort cancer chemopreventive potential of procyanidin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654195/
https://www.ncbi.nlm.nih.gov/pubmed/29071011
http://dx.doi.org/10.5487/TR.2017.33.4.273
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