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Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases
Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654283/ https://www.ncbi.nlm.nih.gov/pubmed/29130003 http://dx.doi.org/10.1155/2017/4141287 |
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author | Alaigh, Vivek Datta, Debapriya |
author_facet | Alaigh, Vivek Datta, Debapriya |
author_sort | Alaigh, Vivek |
collection | PubMed |
description | Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before. |
format | Online Article Text |
id | pubmed-5654283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56542832017-11-12 Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases Alaigh, Vivek Datta, Debapriya Case Rep Crit Care Case Report Tumor lysis syndrome (TLS) is an oncologic emergency characterized by a combination of metabolic derangements (hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia) caused by rapid turnover from cell destruction in certain cancers. These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. TLS occurring spontaneously, without initiation of chemotherapy, is rare and its occurrence in solid tumors is rarer still. We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before. Hindawi 2017 2017-09-11 /pmc/articles/PMC5654283/ /pubmed/29130003 http://dx.doi.org/10.1155/2017/4141287 Text en Copyright © 2017 Vivek Alaigh and Debapriya Datta. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Alaigh, Vivek Datta, Debapriya Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
title | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
title_full | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
title_fullStr | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
title_full_unstemmed | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
title_short | Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases |
title_sort | spontaneous tumor lysis syndrome due to uterine leiomyosarcoma with lung metastases |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654283/ https://www.ncbi.nlm.nih.gov/pubmed/29130003 http://dx.doi.org/10.1155/2017/4141287 |
work_keys_str_mv | AT alaighvivek spontaneoustumorlysissyndromeduetouterineleiomyosarcomawithlungmetastases AT dattadebapriya spontaneoustumorlysissyndromeduetouterineleiomyosarcomawithlungmetastases |