In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases

GH29 α-l-fucosidases catalyze the hydrolysis of α-l-fucosidic linkages. Deficiency in human lysosomal α-l-fucosidase (FUCA1) leads to the recessively inherited disorder, fucosidosis. Herein we describe the development of fucopyranose-configured cyclophellitol aziridines as activity-based probes (ABP...

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Detalles Bibliográficos
Autores principales: Jiang, Jianbing, Kallemeijn, Wouter W., Wright, Daniel W., van den Nieuwendijk, Adrianus M. C. H., Rohde, Veronica Coco, Folch, Elisa Colomina, van den Elst, Hans, Florea, Bogdan I., Scheij, Saskia, Donker-Koopman, Wilma E., Verhoek, Marri, Li, Nan, Schürmann, Martin, Mink, Daniel, Boot, Rolf G., Codée, Jeroen D. C., van der Marel, Gijsbert A., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654414/
https://www.ncbi.nlm.nih.gov/pubmed/29142681
http://dx.doi.org/10.1039/c4sc03739a

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