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Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon

The covalent modification of protein substrates by ubiquitin regulates a diverse range of critical biological functions. Although it has been established that ubiquitin-like modifiers evolved from prokaryotic sulphur transfer proteins it is less clear how complex eukaryotic ubiquitylation system aro...

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Detalles Bibliográficos
Autores principales:	Hennell James, Rory, Caceres, Eva F., Escasinas, Alex, Alhasan, Haya, Howard, Julie A., Deery, Michael J., Ettema, Thijs J. G., Robinson, Nicholas P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654768/ https://www.ncbi.nlm.nih.gov/pubmed/29066714 http://dx.doi.org/10.1038/s41467-017-01162-7

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