Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity

The function of the amyloid precursor protein (APP) in brain health remains unclear. This study elucidated a novel cytoprotective signaling pathway initiated by the APP transcriptionally active intracellular domain (AICD) in response to 27-hydroxycholesterol (27OHC), an oxidized cholesterol metaboli...

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Detalles Bibliográficos
Autores principales: Gongol, Brendan, Marin, Traci L., Jeppson, John D., Mayagoitia, Karina, Shin, Samuel, Sanchez, Nicholas, Kirsch, Wolff M., Vinters, Harry V., Wilson, Christopher G., Ghribi, Othman, Soriano, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654999/
https://www.ncbi.nlm.nih.gov/pubmed/29066835
http://dx.doi.org/10.1038/s41598-017-13933-9

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