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Associations between genetic risk variants for kidney diseases and kidney disease etiology
Chronic kidney disease (CKD) is a global health problem with a genetic component. Genome-wide association studies have identified variants associated with specific CKD etiologies, but their genetic overlap has not been well studied. This study examined SNP associations across different CKD etiologie...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655008/ https://www.ncbi.nlm.nih.gov/pubmed/29066732 http://dx.doi.org/10.1038/s41598-017-13356-6 |
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author | Wunnenburger, Sebastian Schultheiss, Ulla T. Walz, Gerd Hausknecht, Birgit Ekici, Arif B. Kronenberg, Florian Eckardt, Kai-Uwe Köttgen, Anna Wuttke, Matthias |
author_facet | Wunnenburger, Sebastian Schultheiss, Ulla T. Walz, Gerd Hausknecht, Birgit Ekici, Arif B. Kronenberg, Florian Eckardt, Kai-Uwe Köttgen, Anna Wuttke, Matthias |
author_sort | Wunnenburger, Sebastian |
collection | PubMed |
description | Chronic kidney disease (CKD) is a global health problem with a genetic component. Genome-wide association studies have identified variants associated with specific CKD etiologies, but their genetic overlap has not been well studied. This study examined SNP associations across different CKD etiologies and CKD stages using data from 5,034 CKD patients of the German Chronic Kidney Disease study. In addition to confirming known associations, a systemic lupus erythematosus-associated risk variant at TNXB was also associated with CKD attributed to type 1 diabetes (p = 2.5 × 10(−) (7)), a membranous nephropathy-associated variant at HLA-DQA1 was also associated with CKD attributed to systemic lupus erythematosus (p = 5.9 × 10(−) (6)), and an IgA risk variant at HLA-DRB1 was associated with both CKD attributed to granulomatosis with polyangiitis (p = 2.0 × 10(−4)) and to type 1 diabetes (p = 4.6 × 10(−11)). Associations were independent of additional risk variants in the respective genetic regions. Evaluation of CKD stage showed a significant association of the UMOD risk variant, previously identified in population-based studies for association with kidney function, for advanced (stage ≥G3b) compared to early-stage CKD (≤stage G2). Shared genetic associations across CKD etiologies and stages highlight the role of the immune response in CKD. Association studies with detailed information on CKD etiology can reveal shared genetic risk variants. |
format | Online Article Text |
id | pubmed-5655008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56550082017-10-31 Associations between genetic risk variants for kidney diseases and kidney disease etiology Wunnenburger, Sebastian Schultheiss, Ulla T. Walz, Gerd Hausknecht, Birgit Ekici, Arif B. Kronenberg, Florian Eckardt, Kai-Uwe Köttgen, Anna Wuttke, Matthias Sci Rep Article Chronic kidney disease (CKD) is a global health problem with a genetic component. Genome-wide association studies have identified variants associated with specific CKD etiologies, but their genetic overlap has not been well studied. This study examined SNP associations across different CKD etiologies and CKD stages using data from 5,034 CKD patients of the German Chronic Kidney Disease study. In addition to confirming known associations, a systemic lupus erythematosus-associated risk variant at TNXB was also associated with CKD attributed to type 1 diabetes (p = 2.5 × 10(−) (7)), a membranous nephropathy-associated variant at HLA-DQA1 was also associated with CKD attributed to systemic lupus erythematosus (p = 5.9 × 10(−) (6)), and an IgA risk variant at HLA-DRB1 was associated with both CKD attributed to granulomatosis with polyangiitis (p = 2.0 × 10(−4)) and to type 1 diabetes (p = 4.6 × 10(−11)). Associations were independent of additional risk variants in the respective genetic regions. Evaluation of CKD stage showed a significant association of the UMOD risk variant, previously identified in population-based studies for association with kidney function, for advanced (stage ≥G3b) compared to early-stage CKD (≤stage G2). Shared genetic associations across CKD etiologies and stages highlight the role of the immune response in CKD. Association studies with detailed information on CKD etiology can reveal shared genetic risk variants. Nature Publishing Group UK 2017-10-24 /pmc/articles/PMC5655008/ /pubmed/29066732 http://dx.doi.org/10.1038/s41598-017-13356-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wunnenburger, Sebastian Schultheiss, Ulla T. Walz, Gerd Hausknecht, Birgit Ekici, Arif B. Kronenberg, Florian Eckardt, Kai-Uwe Köttgen, Anna Wuttke, Matthias Associations between genetic risk variants for kidney diseases and kidney disease etiology |
title | Associations between genetic risk variants for kidney diseases and kidney disease etiology |
title_full | Associations between genetic risk variants for kidney diseases and kidney disease etiology |
title_fullStr | Associations between genetic risk variants for kidney diseases and kidney disease etiology |
title_full_unstemmed | Associations between genetic risk variants for kidney diseases and kidney disease etiology |
title_short | Associations between genetic risk variants for kidney diseases and kidney disease etiology |
title_sort | associations between genetic risk variants for kidney diseases and kidney disease etiology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655008/ https://www.ncbi.nlm.nih.gov/pubmed/29066732 http://dx.doi.org/10.1038/s41598-017-13356-6 |
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