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Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development
Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study in vivo function of PDK1 in neuron survival during cortical development, we generate forebrain-specific PDK1 conditional knockout (cKO) mice. We demonstrate that PDK1 cKO mice display strikin...
Autores principales: | Xu, Congyu, Yu, Linjie, Hou, Jinxing, Jackson, Rosemary J., Wang, He, Huang, Chaoli, Liu, Tingting, Wang, Qihui, Zou, Xiaochuan, Morris, Richard G., Spires-Jones, Tara L., Yang, Zhongzhou, Yin, Zhenyu, Xu, Yun, Chen, Guiquan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655024/ https://www.ncbi.nlm.nih.gov/pubmed/29104535 http://dx.doi.org/10.3389/fncel.2017.00330 |
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