Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development

Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study in vivo function of PDK1 in neuron survival during cortical development, we generate forebrain-specific PDK1 conditional knockout (cKO) mice. We demonstrate that PDK1 cKO mice display strikin...

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Detalles Bibliográficos
Autores principales: Xu, Congyu, Yu, Linjie, Hou, Jinxing, Jackson, Rosemary J., Wang, He, Huang, Chaoli, Liu, Tingting, Wang, Qihui, Zou, Xiaochuan, Morris, Richard G., Spires-Jones, Tara L., Yang, Zhongzhou, Yin, Zhenyu, Xu, Yun, Chen, Guiquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655024/
https://www.ncbi.nlm.nih.gov/pubmed/29104535
http://dx.doi.org/10.3389/fncel.2017.00330

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