Survival Motor Neuron Protein is Released from Cells in Exosomes: A Potential Biomarker for Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is caused by homozygous mutation of the survival motor neuron 1 (SMN1) gene. Disease severity inversely correlates to the amount of SMN protein produced from the homologous SMN2 gene. We show that SMN protein is naturally released in exosomes from all cell types examine...

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Detalles Bibliográficos
Autores principales: Nash, Leslie A., McFall, Emily R., Perozzo, Amanda M., Turner, Maddison, Poulin, Kathy L., De Repentigny, Yves, Burns, Joseph K., McMillan, Hugh J., Warman Chardon, Jodi, Burger, Dylan, Kothary, Rashmi, Parks, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655039/
https://www.ncbi.nlm.nih.gov/pubmed/29066780
http://dx.doi.org/10.1038/s41598-017-14313-z

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