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Pharmacological Basis of CD101 Efficacy: Exposure Shape Matters

CD101 is a novel echinocandin with concentration-dependent fungicidal activity in vitro and a long half-life (∼133 h in humans, ∼70 to 80 h in mice). Given these characteristics, it is likely that the shape of the CD101 exposure (i.e., the time course of CD101 concentrations) influences efficacy. To...

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Detalles Bibliográficos
Autores principales:	Lakota, Elizabeth A., Bader, Justin C., Ong, Voon, Bartizal, Ken, Miesel, Lynn, Andes, David R., Bhavnani, Sujata M., Rubino, Christopher M., Ambrose, Paul G., Lepak, Alexander J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655053/ https://www.ncbi.nlm.nih.gov/pubmed/28848022 http://dx.doi.org/10.1128/AAC.00758-17

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